Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps.
Precision Medicine in Chronic Rhinosinusitis with Nasal Polyps.
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DOI：
10.1007/s11882-018-0776-8
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发表时间：
2018-03-24
影响因子：
5.5
通讯作者：
Fokkens W
中科院分区：
文献类型：
--
作者：
Avdeeva K;Fokkens W
慢性鼻-鼻窦炎是一种发病率高、严重影响健康相关生活质量(HRQOL)的疾病，它与大量的医疗保健和生产力成本有关。我们面临着提高疾病控制水平，实现更高的患者满意度和疾病预防的迫切需要。精准医疗越来越被认为是最佳患者护理的前进方向。个性化护理、疾病预防、治疗成功的预测和患者参与治疗计划的制定相结合，有望确保对患有慢性残疾的个人采取尽可能最佳的治疗方法。本文对鼻腔和鼻窦慢性炎症的内型、生物标记物和靶向治疗的现状进行了叙述性综述。鼻炎和慢性鼻窦炎(CRS)的不同表型根据症状的严重程度和持续时间、特应性状态、控制水平、合并症以及CRS是否有鼻息肉来描述。其潜在的病理生理机制是不同的，不同的内型被识别。新出现的治疗方法针对特定的病理生理途径或内型。这种内型驱动的治疗方法需要仔细选择可能从特定治疗中受益的患者群体。本文对鼻腔和鼻窦慢性炎症性疾病的内分泌类型、生物标志物和靶向治疗的现状进行了全面综述。
Chronic rhinosinusitis is a disease with high prevalence, significant impact on health-related quality of life (HRQoL) and it is associated with substantial healthcare and productivity costs. We face an urgent need to improve the level of disease control and achieve higher patient satisfaction and disease prevention. Precision medicine is increasingly recognized as the way forward in optimal patient care. The combination of personalized care, prevention of disease, prediction of success of treatment, and participation of the patient in the elaboration of the treatment plan is expected to guarantee the best possible therapeutic approach for individuals suffering from a chronic disabling condition. This is a narrative review on the current state of endotypes, biomarkers, and targeted treatments in chronic inflammatory conditions of the nose and paranasal sinuses. Different phenotypes of rhinitis and chronic rhinosinusitis (CRS) have been described based on symptom severity and duration, atopy status, level of control, comorbidities, and presence or absence of nasal polyps in CRS. The underlying pathophysiological mechanisms are diverse, with different endotypes being recognized. Novel emerging therapies are targeting specific pathophysiological pathways or endotypes. This endotype-driven treatment approach requires careful selection of the patient population who might benefit from a specific treatment. This review provides a comprehensive overview of the current state of endotypes, biomarkers and targeted treatments in chronic inflammatory conditions of the nose and paranasal sinuses.
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影响因子：
12.4
作者：
Hellings, P. W.;Fokkens, W. J.;Bousquet, J.
通讯作者：
Bousquet, J.
影响因子：
12.4
作者：
Hirsch AG;Stewart WF;Sundaresan AS;Young AJ;Kennedy TL;Scott Greene J;Feng W;Tan BK;Schleimer RP;Kern RC;Lidder A;Schwartz BS
通讯作者：
Schwartz BS
影响因子：
14.2
作者：
Gevaert, Philippe;Calus, Lien;Bachert, Claus
通讯作者：
Bachert, Claus
影响因子：
14.2
作者：
Busse, W;Corren, J;Gupta, N
通讯作者：
Gupta, N
影响因子：
120.7
作者：
Bachert, Claus;Mannent, Leda;Sutherland, E. Rand
通讯作者：
Sutherland, E. Rand