Prognosis of Parkinson's disease: Time to stage III, IV, V, and to motor fluctuations
Prognosis of Parkinson's disease: Time to stage III, IV, V, and to motor fluctuations
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DOI：
10.1002/mds.20993
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发表时间：
2006-09-01
影响因子：
8.6
通讯作者：
Mizuno, Yoshikuni
中科院分区：
文献类型：
--
作者：
Sato, Kenichi;Hatano, Taku;Mizuno, Yoshikuni
我们报告了一项日本帕金森病（PD）患者大队列的长期结果。从1989年1月1日至2002年12月31日，共有1768名患者（793名男性，975名女性）连续来我诊所就诊。其中1183例患者（男性531例，女性652例）在发病5年内就诊，首次就诊时在Hoehn & Yahr III期及以下。长期结果是。在这个患者亚队列中进行评估。我们检查了达到第111期、第IV期和第V期的持续时间，以及出现磨损和运动障碍的持续时间。女性进入第三阶段的时间略短，但明显较短，在第5年结束时，23.8%的男性和35.3%的女性进入第三阶段；49.7%的男性和63.3%的女性在第10年末达到III期，88.9%的男性和79.9%的女性在第15年末达到III期（P < 0.001）。此外，女性出现疲劳和运动障碍的持续时间也比男性短。这些数据表明，女性的病情进展可能稍快一些。年轻起病的患者达到第111期、第IV期和第V期的时间明显较长，但出现磨损和运动障碍的时间较短。文献中关于PD长期预后的研究并不多，我们的数据可以作为参考。(c) 2006年运动障碍协会。
We report a long-term, outcome on a large cohort of Japanese patients with Parkinson's disease (PD). A total of 1,768 (793 men, 975 women) consecutive patients visited our clinic from I January 1989 to 31 December 2002. Among them, 1, 183 patients (531 men, 652 women) came to our clinic within 5 years from the onset of disease and at the Hoehn & Yahr Stage III or less at the first visit. Long-term outcome was. evaluated in this subcohort of the patients. We examined the duration to reach Stage 111, IV, and V, and the duration to develop wearing off and dyskinesia. Time to reach Stage III was slightly but significantly shorter in women, in that 23.8% of men and 35.3% of women reached Stage III by the end of the 5th year; 49.7% of men and 63.3% of women reached Stage III by the end of the 10th year, and 88.9% of men and 79.9% of women by the end of the 15th year (P < 0.001). Also, durations to develop wearing off and dyskinesia were shorter in women compared to men. These data suggest that the disease progression may be slightly faster for women. Young-onset patients showed significantly longer duration to reach Stage 111, IV, and V but shorter duration to develop wearing off and dyskinesia. Not many studies are available in the literature on the long-term outcome of PD, and our data would be useful as a reference. (c) 2006 Movement Disorder Society.