Chronic Exposure to Outdoor Air Pollution and Markers of Systemic Inflammation
Chronic Exposure to Outdoor Air Pollution and Markers of Systemic Inflammation
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DOI：
10.1097/ede.0b013e318190ea3f
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发表时间：
2009-03-01
期刊：
影响因子：
5.4
通讯作者：
Anderson, Ross H.
中科院分区：
文献类型：
--
作者：
Forbes, Lindsay J. L.;Patel, Minal D.;Anderson, Ross H.
工作背景：队列研究表明，长期暴露于较高水平的室外空气污染会增加患心血管疾病的风险。一种可能的机制是，空气污染，尤其是颗粒物，会诱发全身性炎症，从而增加心血管系统发生长期病理变化的风险。我们的目的是研究长期暴露于较高水平的空气污染与慢性全身性炎症之间的关联。我们研究了两种全身性炎症标志物之间的关系，（纤维蛋白原和C反应蛋白）和室外空气污染的措施估计每个邮政编码区的居住，使用模型，将来自多个来源的污染物排放的信息，和大气扩散和处理，在1994年，1998年和2003年的英国人口的3个代表性的横断面研究。其中包括约25，000名纤维蛋白原测量的成年人和17，000名C反应蛋白测量的成年人。我们使用多水平线性回归模型，并使用荟萃分析汇总了3项调查的结果。结果：我们没有发现纤维蛋白原或C反应蛋白浓度与室外空气污染（颗粒物）测量之间存在关联
Background: Cohort studies suggest that long-term exposure to higher levels of outdoor air pollution increases risk of developing cardiovascular disease. One suggested mechanism is that air pollution, especially particulate matter, induces systemic inflammation, thereby increasing the risk of developing long-term pathologic changes in the cardiovascular system, We aimed to examine the association between long-term exposure to higher levels of air pollution and chronic systemic inflammation.Methods: We examined the relationship between 2 markers of systemic inflammation (fibrinogen and C-reactive protein) and measures of outdoor air pollution estimated for each postcode sector of residence, using models incorporating information on pollutant emissions from multiple sources, and atmospheric dispersion and processing, in 3 representative cross-sectional studies of the English population in 1994, 1998, and 2003. These included about 25,000 adults with fibrinogen measurements and 17,000 adults with C-reactive protein measurements. We used multilevel linear regression modeling and pooled the results from the 3 surveys using meta-analysis.Results: We found no associations between concentrations of fibrinogen or C-reactive protein and measures of outdoor air pollution (particulate matter