Apoptosis in hepatocellular carcinoma.
Apoptosis in hepatocellular carcinoma.
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DOI：
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发表时间：
2003
影响因子：
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通讯作者：
J. Kountouras;C. Zavos;D. Chatzopoulos
中科院分区：
文献类型：
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作者：
J. Kountouras;C. Zavos;D. Chatzopoulos
细胞凋亡过程在多种生理和病理生理过程中起着至关重要的作用，并且是删除不需要的、衰老的或受损的细胞的基本机制。细胞凋亡机制的缺陷，或者甚至更多的是细胞复制、生长、分化和细胞凋亡之间的平衡紊乱，有利于肝脏中癌前病变和肿瘤病变的生长。临床和分子医学分析已经产生了大量有关肝脏肿瘤发生的信息。对肝癌发生的转基因模型的研究已经允许对细胞凋亡、肿瘤抑制因子、DNA修复过程和遗传损伤的克隆扩张和积累中的其他事件的作用进行细致的检查。在启动期间，存在快速增殖和大量凋亡，而在促进阶段，存在减少的细胞死亡和增加的细胞增殖。越来越多的证据表明，在人类肝细胞癌细胞凋亡过程中的缺陷。此外，一系列与细胞凋亡相关的预后因素可用于早期评估肝癌发生的进展以及肝癌复发。最后，许多潜在的治疗策略，以各种方式诱导凋亡过程，可以应用于肝细胞癌的管理。
The process of apoptosis plays a crucial role in several physiological as well as pathophysiological processes, and is a fundamental mechanism for the deletion of unwanted, senescent, or damaged cells. Defects in the apoptotic mechanisms or, even more, disturbances of the equilibrium between cellular replication, growth, differentiation and apoptosis favor the growth of preneoplastic and tumoral lesions in the liver. Clinical and molecular medical analyses have yielded a considerable amount of information about liver oncogenesis. Studies on transgenic models of hepatocarcinogenesis have allowed a meticulous examination of the roles of apoptosis, tumor suppressors, DNA repair processes and other events in the clonal expansion and accumulation of genetic lesions. During initiation, there is rapid proliferation and a high amount of apoptosis, whereas in the promotion stage, there is decreased cell death and increased cell proliferation. Accumulating evidence suggests a defective apoptotic process in human hepatocellular carcinoma. Moreover, a range of prognostic factors related to apoptosis might be used in the early assessment of the progress of hepatocarcinogenesis as well as in hepatocellular carcinoma recurrence. Lastly, many potential therapeutic strategies, that induce the apoptotic process in various ways, can be applied to the hepatocellular carcinoma management.