Characterization of the Mycobacterium tuberculosis phagosome
Characterization of the Mycobacterium tuberculosis phagosome
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DOI：
10.1016/0966-842x(96)81528-9
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发表时间：
1996-03-01
影响因子：
15.9
通讯作者：
Clemens, DL
中科院分区：
文献类型：
--
作者：
Clemens, DL
结核分枝杆菌寄生于宿主巨噬细胞中，并存在于不与溶酶体融合并抵抗酸化的吞噬体中。与含惰性颗粒的吞噬体相比，M.结核病吞噬体表现出成熟停滞：质膜蛋白和早期内吞标记物持续存在，溶酶体标记物的获得有限。
Mycobacterium tuberculosis parasitizes host macrophages and resides in a phagosome that does not fuse with lysosomes and that resists acidification. Compared with phagosomes containing inert particles, the M. tuberculosis phagosome exhibits maturational arrest: plasma membrane proteins and early endocytic markers persist and there is limited acquisition of lysosomal markers.