Normothermic Machine Preservation of the Liver: State of the Art.
Normothermic Machine Preservation of the Liver: State of the Art.
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DOI：
10.1007/s40472-018-0186-9
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发表时间：
2018
影响因子：
2.1
通讯作者：
Jassem W
中科院分区：
文献类型：
--
作者：
Ceresa CDL;Nasralla D;Jassem W
本文就常温机器灌注的概念及其在肝移植中的作用作一综述。通过讨论最近临床研究的结果并强调该技术提供的潜在机会，我们的目标是更深入地了解NMP及其在增强肝移植方面的作用。NMP最近被证明在肝移植中是安全可行的，并且在早期生化肝功能方面也证明了其优于传统冷藏。通过在保存期间进行生存力评估和延长保存时间的能力，很可能会增加器官利用率。NMP可能有助于增强保存，改善心脏性死亡和脂肪变性肝脏后供体的结局。此外，它为肝脏定向治疗干预提供了令人兴奋的潜力。迄今为止的证据表明，NMP有助于增强肝移植物的保存，改善移植后早期结局。这项技术的关键作用是增加可用于移植的肝移植物的数量和质量，并减少等待名单上的死亡人数。
This review aims to introduce the concept of normothermic machine perfusion (NMP) and its role in liver transplantation. By discussing results from recent clinical studies and highlighting the potential opportunities provided by this technology, we aim to provide a greater insight into NMP and the role it can play to enhance liver transplantation. NMP has recently been shown to be both safe and feasible in liver transplantation and has also demonstrated its superiority to traditional cold storage in terms of early biochemical liver function. Through the ability to perform a viability assessment during preservation and extend preservation times, it is likely that an increase in organ utilisation will follow. NMP may facilitate the enhanced preservation with improved outcomes from donors after cardiac death and steatotic livers. Furthermore, it provides the exciting potential for liver-directed therapeutic interventions. Evidence to date suggests that NMP facilitates the enhanced preservation of liver grafts with improved early post-transplant outcomes. The key role for this technology is to increase the number and quality of liver grafts available for transplantation and to reduce waiting list deaths.