Close to threshold transcranial electrical stimulation preferentially activates inhibitory networks before switching to excitation with higher intensities
Close to threshold transcranial electrical stimulation preferentially activates inhibitory networks before switching to excitation with higher intensities
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DOI：
10.1016/j.brs.2011.11.004
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发表时间：
2012-10-01
影响因子：
7.7
通讯作者：
Paulus, Walter
中科院分区：
文献类型：
--
作者：
Moliadze, Vera;Atalay, Deniz;Paulus, Walter
背景资料：最近，我们已经证明，经颅随机噪声（tRNS）和140 Hz经颅交流电刺激（tACS），应用于初级运动皮层（M1），并使用10 min的刺激持续时间和1 mA的强度，显着增加皮层兴奋性，如运动诱发电位在刺激前后的休息测量。目的/假设：在这里，通过从1.0 mA的0.2 mA的步骤减少刺激强度，我们调查到什么程度的强度取决于诱导after-effects.Methods：所有25名受试者参加了两个不同的实验会话。他们在不同的日子接受了使用140 Hz频率的tACS和五种不同强度的全谱tRNS。假刺激被用作control.Results：而不是接收一个简单的阈值，出乎意料的是，在这两个独立的数据集在阈值强度为0.4 mA，我们发现了一个开关的已经知道的兴奋实现与1 mA的强度抑制。0.6和0.8 mA的中间强度范围根本没有影响。有趣的是，由140 Hz的tACS产生的抑制比诱导tRNS.Conclusions：总之，我们已经表明，在这里选择性地控制M1兴奋性的增强或降低，通过施加不同强度的高频经颅电刺激的可能性。(C)2012 Elsevier Inc. All rights reserved.
Background: Recently we have shown that transcranial random noise (tRNS) and 140 Hz transcranial alternating current stimulations (tACS), applied over the primary motor cortex (M1) and using 10 min stimulation duration and 1 mA intensity, significantly increases cortical excitability as measured by motor evoked potentials at rest before and after stimulation.Objective/hypothesis: Here, by decreasing the stimulation intensity in 0.2 mA steps from 1.0 mA, we investigate to what extent intensity depends on the induced after-effects.Methods: All twenty-five subjects participated in two different experimental sessions each. They received tACS using 140 Hz frequency and full spectrum tRNS at five different intensities on separate days. Sham stimulation was used as a control.Results: Instead of receiving a simple threshold, unexpectedly, in these two independent data sets at threshold intensities of 0.4 mA we found a switch of the already known excitation achieved with an intensity of 1 mA to inhibition. The intermediate intensity ranges of 0.6 and 0.8 mA had no effect at all. Interestingly, the inhibition produced by 140 Hz tACS was stronger than that induced by tRNS.Conclusions: In summary, we have shown here the possibility of selectively controlling the enhancement or reduction of M1 excitability by applying different intensities of high frequency transcranial electrical stimulation. (C) 2012 Elsevier Inc. All rights reserved.