Novel codeinone derivatives via Michael addition of barbituric acids
Novel codeinone derivatives via Michael addition of barbituric acids
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DOI：
10.1016/j.tetasy.2009.02.005
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发表时间：
2009-02-26
影响因子：
--
通讯作者：
Koleva, Bojidarka B.
中科院分区：
文献类型：
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作者：
Kolev, Tonko;Bakalska, Rumjana;Koleva, Bojidarka B.
通过Michael加成反应合成了两种新的可待因酮与巴比妥酸和2-硫代巴比妥酸的加合物。化合物通过定向样品的IR-LD光谱学作为在水相液晶中的悬浮液、UV光谱学和H-1和C-13 NMR光谱学进行光谱学解析。2-硫代巴比妥加合物，其特征在于通过X-射线晶体学。还采用了高效液相色谱串联质谱法（HPLC ESI MS/MS）和热分析法。量子化学计算已经进行，以期获得的电子结构和振动性质的新化合物。(C)2009爱思唯尔有限公司保留所有权利。
Two novel adducts of codeinone with barbituric and 2-thiobarbituric acids have been synthesized via Michael addition. The compounds were spectroscopically elucidated by means of IR-LD spectroscopy of oriented samples as a suspension in nematic liquid crystals, UV spectroscopy and H-1 and C-13 NMR spectroscopy. The 2-thiobarbituric adduct was characterized by X-ray crystallography. HPLC tandem mass spectrometry (HPLC ESI MS/MS) and thermal methods were also employed. Quantum chemical calculations have been performed with a view to obtaining the electronic structure and vibrational properties of the novel compounds. (C) 2009 Elsevier Ltd. All rights reserved.