Hyperacute Diffusion-Weighted Imaging Abnormalities in Transient Ischemic Attack Patients Signify Irreversible Ischemic Infarction
Hyperacute Diffusion-Weighted Imaging Abnormalities in Transient Ischemic Attack Patients Signify Irreversible Ischemic Infarction
复制标题
短暂性脑缺血发作患者的超急性弥散加权成像异常意味着不可逆的缺血性梗死
DOI：
10.1159/000085203
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发表时间：
2005
影响因子：
2.9
通讯作者：
M. Uchino
中科院分区：
文献类型：
--
作者：
Y. Inatomi;K. Kimura;T. Yonehara;S. Fujioka;M. Uchino
背景资料：描述短暂性脑缺血发作（TIA）超急性期弥散加权成像（DWI）异常的频率和临床特征。研究方法：我们对21例TIA患者（平均年龄64岁; 17例男性和4例女性）在超急性期（发病后6小时内）和亚急性期（发病后2-9天内）进行了DWI。结果：超急性期DWI异常11例（阳性组），阴性组10例（阴性组）。根据临床特征无法区分这些组。在亚急性期，阳性组的所有11例患者在MRI上均出现异常，包括T2加权和液体衰减反转恢复图像以及DWI，病变位于与超急性期观察到的病变相似的区域。阴性组10例患者中，2例在亚急性期观察到新发DWI异常。结论：在超急性期进行MRI的TIA患者中，约有一半存在DWI异常，所有这些异常在亚急性期都持续存在。研究结果表明，TIA患者的所有超急性DWI异常都可能提示不可逆性，并意味着脑梗死的存在。
Background: To characterize the frequency and clinical features of diffusion-weighted imaging (DWI) abnormalities in the hyperacute phase of transient ischemic attacks (TIAs). Methods: We performed DWI in 21 consecutive patients with TIA (mean age 64 years; 17 men and 4 women) during both the hyperacute phase (within 6 h after onset) and subacute phase (within 2–9 days after onset). Results: DWI abnormalities were present in the hyperacute phase in 11 patients (positive group) and absent in the other 10 patients (negative group). These groups could not be differentiated based on the clinical characteristics. In the subacute phase, all 11 patients from the positive group had abnormalities on MRI including T2-weighted and fluid attenuation inversion recovery images as well as DWI, with lesions being located in regions similar to those observed in the hyperacute phase. Of the 10 patients in the negative group, new DWI abnormalities were noted in 2 during the subacute phase. Conclusions: Approximately half of TIA patients in whom MRI was performed in the hyperacute phase had DWI abnormalities, all of which persisted in the subacute phase. The findings suggest that essentially all hyperacute DWI abnormalities in TIA patients may indicate irreversibility and signify the presence of brain infarction.