Skeletal malocclusion: a developmental disorder with a life-long morbidity.
Skeletal malocclusion: a developmental disorder with a life-long morbidity.
复制标题
骨骼障碍：一种发育障碍，具有终生发病率。
DOI：
10.14740/jocmr1905w
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Fakhouri WD
中科院分区：
文献类型：
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作者：
Joshi N;Hamdan AM;Fakhouri WD
由于面部结构和发育的复杂性以及对内在和外在扰动的敏感性，口面组织中出生缺陷的可能性很高。骨性错牙合畸形是由于胎儿发育过程中下颌骨和/或上颌骨的正常生长扭曲而引起的。骨骼咬合不正的病人如不加以治疗，可能会出现牙齿畸形、磨牙症、牙齿拥挤、牙关紧闭、咀嚼困难、呼吸困难及消化不良等问题。在这篇综述中，我们关注的是影响27.9%的美国人口的不同严重程度的骨性错牙合。我们总结了不同种族人群中I类、II类和III类错牙合畸形的患病率，并讨论了与骨性错牙合畸形相关的最常见的内科疾病。牙齿异常导致错牙合畸形，如牙齿发育不全，拥挤，牙齿缺失和牙齿大小异常没有在这篇综述中讨论。我们提出了一个修改后的版本的错牙合分类的研究目的，表现出明确的区别骨骼与牙齿错牙合相比，角度的分类。此外，我们通过BigMouth Dental Data Repository对正畸（错牙合）数据进行了横断面分析，以计算错牙合与其他医疗条件之间的潜在关联。总之，这篇评论强调，需要确定遗传和环境因素，导致或有助于风险的骨骼错牙合和可能与其他医疗条件，以改善评估，预后和治疗方法。
The likelihood of birth defects in orofacial tissues is high due to the structural and developmental complexity of the face and the susceptibility to intrinsic and extrinsic perturbations. Skeletal malocclusion is caused by the distortion of the proper mandibular and/or maxillary growth during fetal development. Patients with skeletal malocclusion may suffer from dental deformities, bruxism, teeth crowding, trismus, mastication difficulties, breathing obstruction and digestion disturbance if the problem is left untreated. In this review, we focused on skeletal malocclusion that affects 27.9% of the US population with different severity levels. We summarized the prevalence of class I, II and III of malocclusion in different ethnic groups and discussed the most frequent medical disorders associated with skeletal malocclusion. Dental anomalies that lead to malocclusion such as tooth agenesis, crowding, missing teeth and abnormal tooth size are not addressed in this review. We propose a modified version of malocclusion classification for research purposes to exhibit a clear distinction between skeletal vs. dental malocclusion in comparison to Angle’s classification. In addition, we performed a cross-sectional analysis on orthodontic (malocclusion) data through the BigMouth Dental Data Repository to calculate potential association between malocclusion with other medical conditions. In conclusion, this review emphasizes the need to identify genetic and environmental factors that cause or contribute risk to skeletal malocclusion and the possible association with other medical conditions to improve assessment, prognosis and therapeutic approaches.