Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine.
Inter-operator Reliability of Magnetic Resonance Image-Based Computational Fluid Dynamics Prediction of Cerebrospinal Fluid Motion in the Cervical Spine.
复制标题
基于磁共振图像的颈椎脑脊液运动的计算流体动力学预测的操作者间可靠性。
DOI：
10.1007/s10439-015-1449-6
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发表时间：
2016
影响因子：
3.8
通讯作者：
Stergiopulos,Nikolaos
中科院分区：
文献类型：
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作者：
Martin,BrynA;Yiallourou,TheresiaI;Pahlavian,SoroushHeidari;Thyagaraj,Suraj;Bunck,AlexanderC;Loth,Francis;Sheffer,DanielB;Kröger,JanRobert;Stergiopulos,Nikolaos
首次评估了基于MRI的计算流体动力学(CFD)颈椎蛛网膜下腔(SSS)脑脊液(CSF)模型的操作者间相关性。在活体MRI血流测量和解剖图像中，在一个健康受试者和一个Chiari I畸形患者的颈髓交界处获得了MRI图像。由4个独立的操作者对两个病例的SSs进行手工分割重建SSS的三维解剖。比较了SSS沿线9个轴向位置的流体力学和几何参数的计算结果。组内相关(ICC)评估各参数在轴向位置上的符合性，并比较各参数在不同操作者之间的变异百分比。与健康受试者(ICC：0.78)相比，患者在头颈交界处对操作者的依赖性更强(0.19；ICC：0.99)。在健康受试者中，水力直径和沃姆斯利数的变异最小(CV=0~2%)。患者的舒张期峰值血流速度和雷诺数的变异最小(CV=0~3%)。这些结果表明，对于健康受试者，基于MRI的CFD模拟颈椎中的脑脊液流动具有较高的操作者间可靠性，而对于I型Chiari畸形患者，可靠性较低。
For the first time, inter-operator dependence of MRI based computational fluid dynamics (CFD) modeling of cerebrospinal fluid (CSF) in the cervical spinal subarachnoid space (SSS) is evaluated.In vivoMRI flow measurements and anatomy MRI images were obtained at the cervico-medullary junction of a healthy subject and a Chiari I malformation patient. 3D anatomies of the SSS were reconstructed by manual segmentation by four independent operators for both cases. CFD results were compared at nine axial locations along the SSS in terms of hydrodynamic and geometric parameters. Intraclass correlation (ICC) assessed the inter-operator agreement for each parameter over the axial locations and coefficient of variance (CV) compared the percentage of variance for each parameter between the operators. Greater operator dependence was found for the patient (0.19 < ICC < 0.99) near the craniovertebral junction compared to the healthy subject (ICC > 0.78). For the healthy subject, hydraulic diameter and Womersley number had the least variance (CV = ~2%). For the patient, peak diastolic velocity and Reynolds number had the smallest variance (CV = ~3%). These results show a high degree of inter-operator reliability for MRI-based CFD simulations of CSF flow in the cervical spine for healthy subjects and a lower degree of reliability for patients with Type I Chiari malformation.