The influence of stimulating electrode conditions on electrically evoked potentials and resistance in suprachoroidal transretinal stimulation
The influence of stimulating electrode conditions on electrically evoked potentials and resistance in suprachoroidal transretinal stimulation
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DOI：
10.1007/s10384-022-00972-7
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发表时间：
2023-01-10
影响因子：
2.4
通讯作者：
Nishida，Kohji
中科院分区：
文献类型：
--
作者：
Nishida，Kentaro;Morimoto，Takeshi;Nishida，Kohji
目的探讨刺激电极条件对脉络膜下经视网膜上电刺激(STS)系统中电诱发电位(EEPS)波幅、潜伏期及电极-组织界面电阻的影响。研究设计实验研究。方法在麻醉色兔(体重1.9~2.7 kg)的视纹上方制作3×5 mm的巩膜袋，植入STS刺激电极。使用不同长度(0.3或0.5 mm)和不同表面特征(光滑或多孔)的刺激电极进行测量。记录每组电极条件下以固定电流激发的EEPS；对每只兔进行三次测量。结果刺激电极的高度和表面特性改变，刺激电极的潜伏期和波幅无显著差异，但电极-组织界面的电阻有显著差异(P=0.001；0.3 mm多孔电极的电阻值为5.2 4±0.67kΩ，0.3 mm和0.5 mm光滑电极的电阻值分别为7.6 3±0.12 kΩ和6.77±0.2 0 kΩ。
PurposeTo determine the influence of stimulating electrode conditions on the amplitudes and latencies of electrically evoked potentials (EEPs) and the resistance at the electrode–tissue interface in the suprachoroidal transretinal stimulation (STS) system.Study designExperimental study.MethodsA scleral pocket (3 × 5 mm) was created just over the visual streak in anesthetized pigmented rabbits (weight, 1.9-2.7 kg), and STS stimulating electrodes were implanted into the pocket. Measurements were obtained with stimulating electrodes of different lengths (0.3 or 0.5 mm) and different surface characteristics (smooth or porous). EEPs elicited with a fixed current under each set of electrode conditions were recorded; three measurement sessions were performed for each rabbit. The resistance at each electrode–tissue interface was measured.ResultsThe latencies and amplitudes of the EEPs did not differ significantly with changes in the height and surface characteristics of the stimulating electrodes, but the resistances at the electrode–tissue interface differed significantly (P = 0.001; the resistance values for the 0.3-mm-long electrode with a porous surface was 5.24 ± 0.67 kΩ and with the 0.3- and 0.5-mm-long electrodes with smooth surfaces were 7.63 ± 0.12 kΩ and 6.77 ± 0.20 kΩ).ConclusionBeing shorter did not affect the EEPs of the stimulating electrodes with a porous surface while decreasing the resistance at the electrode–tissue interface.