Hamsters running on time: Is the lateral habenula a part of the clock?
Hamsters running on time: Is the lateral habenula a part of the clock?
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DOI：
10.1080/07420520500521947
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发表时间：
2006-01-01
影响因子：
2.8
通讯作者：
Schwartz, WJ
中科院分区：
文献类型：
--
作者：
Tavakoli-Nezhad, M;Schwartz, WJ
以往的解剖学和生理学研究表明，外侧缰核，特别是其内侧分裂(LHbM)，是啮齿类动物昼夜节律系统的候选组成部分。我们用c-fos免疫组织化学方法分析了啮齿动物外侧缰核的节律性，发现LHbM的免疫反应细胞计数有很强的节律性，在明暗周期的黑暗阶段和在持续黑暗的主观夜晚，免疫反应细胞计数较高。我们还观察到c-fos在恒光下行为分裂仓鼠的LHbM中表达的明显不对称性，但仅在它们的活动期(当它们在轮子上奔跑时)。运动活动节律似乎受视交叉上核(SCN)通过多条输出路径调节，其中一条可能是扩散的，另一条可能是神经的，涉及外侧缰核。
Previous anatomical and physiological studies have implicated the lateral habenula, and especially its medial division (LHbM), as a candidate component of the circadian timing system in rodents. We assayed lateral habenula rhythmicity in rodents using c-FOS immunohistochemistry and found a robust rhythm in immunoreactive cell counts in the LHbM, with higher counts during the dark phase of a light-dark (LD) cycle and during subjective night in constant darkness. We have also observed an obvious asymmetry of c-FOS expression in the LHbM of behaviorally "split hamsters in constant light, but only during their active phase (when they were running in wheels). Locomotor activity rhythms appear to be regulated by the suprachiasmatic nucleus (SCN) via multiple output pathways, one of which might be diffusible while the other might be neural, involving the lateral habenula.