Evidence for the conservation of an immunoreactive monokine network in invertebrates.
Evidence for the conservation of an immunoreactive monokine network in invertebrates.
复制标题
无脊椎动物中免疫反应性单核因子网络保存的证据。
DOI：
10.1111/j.1749-6632.1992.tb49098.x
复制
发表时间：
1992
影响因子：
5.2
通讯作者：
Stefano,GB
中科院分区：
文献类型：
--
作者：
HughesJr,TK;Smith,EM;Leung,MK;Stefano,GB
The observations that similar molecules are both produced by and elicit re-sponses in the immune and neuroendocrine systems strongly suggests a linkage between the two in vertebrates."* Recent studies have shown that this linkage also appears to exist in invertebrates." Most notably, several reports have demonstrated that common molecules are present in both systems of the marine bivalve mollusc, Mytilus edulis.** For example, Mytilus hemocytes and human granulocytes dem-onstrate similar conformational changes and locomotory responses following expo-sure to opioid peptides and also appear to produce an immunoreactive (ir)[Met] enkephalin." The hemocytes of Mytilus exhibit similarities to cells of the vertebrate monocyte/macrophage lineage. For example, they are motile, phagocytic and contain myeloperoxidase."" Additionally, when a nerve is severed, Mytilus evokes an immune-like response demonstrated by migration of hemocytes into the lesioned area." Considering the similarities of Mytilus hemocytes and human monocytes we determined whether a monokine-like network might be operating in these invertebrates. We have found that Mytilus hemocytes respond to human monokines, interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF), contain immuno-
