Frontotemporal dementia and Alzheimer disease: Evaluation of cortical atrophy with automated hemispheric surface display generated with MR images
Frontotemporal dementia and Alzheimer disease: Evaluation of cortical atrophy with automated hemispheric surface display generated with MR images
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DOI：
10.1148/radiology.208.2.9680572
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发表时间：
1998-08-01
期刊：
影响因子：
19.7
通讯作者：
Hata, Y
中科院分区：
文献类型：
--
作者：
Kitagaki, H;Mori, E;Hata, Y
目的：利用磁共振(MR)图像生成的半球表面显示技术，确定额颞叶痴呆(FTD)和阿尔茨海默病(AD)患者大脑皮质萎缩的特征。材料和方法：应用自动MR半球表面显示和体积测量技术对18例FTD患者和18例匹配的阿尔茨海默病患者的大脑皮质萎缩程度进行评估。结果：FTD和阿尔茨海默病患者的大脑皮层大部分区域明显萎缩。与阿尔茨海默病组相比，FTD组的额叶和前颞叶明显萎缩。FTD患者(56.2%)和阿尔茨海默病患者(58.4%)的平均半球/颅内体积比(66.0%)明显小于对照组(66.0%)。大脑半球体积的不对称性在FTD组明显大于阿尔茨海默病组和对照组。结论：FTD的皮质萎缩比先前认为的更普遍。额叶和前颞叶的不对称性萎缩是FTD的一个显著特征，它与阿尔茨海默病不同。大脑半球表面显示是对断层图像的有益补充，对评估退行性痴呆，特别是FTD的局灶性皮质萎缩是有用的。
PURPOSE: To determine the features of cortical atrophy in frontotemporal dementia (FTD) and Alzheimer diseases by using a hemispheric surface display generated with magnetic resonance (MR) images.MATERIALS AND METHODS: The extent of cortical atrophy was evaluated with automated MR hemispheric surface display and volumetry in 18 patients with FTD and in 18 matched patients with Alzheimer disease. Results were compared with those in 18 healthy, matched control subjects.RESULTS: Most cortical regions were significantly atrophic in FTD and Alzheimer disease. The frontal and anterior temporal lobes were significantly ore atrophic in FTD than in Alzheimer disease. The mean hemispheric-to-intracranial volume ratio in patients with FTD (56.2%) and those withe Alzheimer disease (58.4%) was significantly smaller than the ratio in the control subjects (66.0%). Asymmetry of hemispheric volume was significantly larger in the FTD group than in the Alzheimer disease and control groups.CONCLUSION: Cortical atrophy in FTD is more widespread than was previously thought. Asymmetric frontal and anterior temporal atrophy is a distinctive feature of FTD and distinguishes it from Alzheimer disease. Hemispheric surface display is a useful complement to tomographic images and is useful for the evaluation of focal cortical atrophy in degenerative dementias, especially FTD.