Mouse models of holoprosencephaly.
Mouse models of holoprosencephaly.
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前脑无裂畸形小鼠模型。
DOI：
10.1097/01.wco.0000063761.15877.40
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发表时间：
2003
影响因子：
4.8
通讯作者：
McConnell,SusanK
中科院分区：
文献类型：
--
作者：
Hayhurst,Monica;McConnell,SusanK
小鼠HPE的研究为理解人类大脑发育中的关键发育事件提供了框架，并可能为人类HPE提供新的候选基因。尽管取得了这一进展，但关于腹侧脑区分子如何最终破坏背侧脑区大脑半球的形成，仍然存在根本性的谜团。
Studies of HPE in the mouse have provided a framework for understanding key developmental events in human brain development and may provide new candidate genes for human HPE. Despite this progress, fundamental mysteries remain about how molecules that pattern ventral brain regions ultimately disrupt the formation of the cerebral hemispheres in dorsal regions.