Interrelationship between exposure to PCDD/Fs and hypertension in metabolic syndrome in Taiwanese living near a highly contaminated area
Interrelationship between exposure to PCDD/Fs and hypertension in metabolic syndrome in Taiwanese living near a highly contaminated area
复制标题
DOI：
10.1016/j.chemosphere.2010.08.050
复制
发表时间：
2010-11-01
期刊：
影响因子：
8.8
通讯作者：
Lee, C. C.
中科院分区：
文献类型：
--
作者：
Chang, J. W.;Ou, H. Y.;Lee, C. C.
代谢综合征(METS)由一系列代谢异常组成，这些代谢异常增加了心血管疾病的风险。接触持久性有机污染物与METs呈正相关。我们研究了居住在二恶英高度污染地区附近的1490名非糖尿病患者的二恶英/二恶英和蛋氨酸组分之间的关联。我们使用因子分析，将一组核心变量视为蛋氨酸和多氯二苯并二恶英/呋喃的中心特征，以将类似的危险因素分组。血清PCDD/FS与蛋氨酸组分呈显著正相关。在10个核心因素中，四个危险因素--血脂、血压、体型和血糖--解释了72.6%的变异，PCDD/F通过与高血压的共同相关性与蛋氨酸代谢综合征联系在一起。在调整混杂因素后，我们发现舒张压(β=0.018；p=0.006)、血糖(β=0.013；p=0.046)和腰围(β=0.721；p=0.042)随着血清PCDD/F水平的升高而显著增加。我们发现代谢综合征与血清低氯二恶英/二恶英之间的相关性有显著的趋势。最高五分位数的2，3，4，7.8-PeCDF、1，2，3，6，7，8-HxCDF和2，3，7，8-TCDD的调整OR值(95%CI)分别为3.5(1.9-6.3)、2.9(1.7-4.9)和2.8(1.6-4.9)。我们还发现血清PCDD/FS与Mets的患病率之间存在轻微的单调关系，特别是当血清二恶英水平高于25.4pg WHO98-TEQ(Df)g(-1)脂质(四分之四)时。我们假设高剂量暴露于二恶英/二恶英是与血压相关的因素，会增加蛋氨酸的风险。(C)2010爱思唯尔有限公司。保留所有权利。
Metabolic syndrome (MetS) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease. There is a positive correlation between exposure to persistent organic pollutants and MetS. We examine the association between PCDD/Fs and MetS components in 1490 non-diabetic persons living near a highly dioxin-contaminated area. We used factor analysis, with a set of core variables considered central features of MetS and PCDD/Fs, to group similar risk factors. Serum PCDD/Fs were positively and significantly correlated with the number of MetS components. Four risk factors-lipidemia, blood pressure, body size, and glycemia-accounted for 72.6% of the variance in the 10 core factors, and PCDD/Fs were linked to MetS through shared correlations with high blood pressure. After adjusting for confounding factors, we found that diastolic blood pressure (beta = 0.018; p = 0.006), glucose ((beta = 0.013; p = 0.046), and waist circumference (beta = 0.721; p = 0.042) significantly increased with increasing serum PCDD/F levels. We found significant trends for associations between metabolic syndrome and serum low-chlorinated PCDD/Fs. The highest quintiles of 2,3,4,7.8-PeCDF, 1,2,3,6,7,8-HxCDF and 2,3,7,8-TCDD had the top three adjusted ORs (95% CI) of 3.5 (1.9-6.3), 2.9 (1.7-4.9) and 2.8 (1.6-4.9), respectively. We also found a slight monotonic relationship between serum PCDD/Fs and the prevalence of MetS, especially when the serum dioxin level was higher than 25.4 pg WHO98-TEQ(DF) g(-1) lipid (the fourth Quintile). We hypothesize that high-dose exposure to PCDD/Fs is a blood pressure-related factor that raises MetS risk. (C) 2010 Elsevier Ltd. All rights reserved.