Association between depressive symptoms and objectively measured daily step count in individuals at high risk of cardiovascular disease in South London, UK: a cross-sectional study
Association between depressive symptoms and objectively measured daily step count in individuals at high risk of cardiovascular disease in South London, UK: a cross-sectional study
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DOI：
10.1136/bmjopen-2017-020942
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发表时间：
2018-04-01
期刊：
影响因子：
2.9
通讯作者：
Ismail, Khalida
中科院分区：
文献类型：
--
作者：
Ludwig, Vera M.;Bayley, Adam;Ismail, Khalida
目的抑郁症状是常见的，但很少被认为是与心血管疾病（CVD）相关的不健康生活方式的危险因素。本研究调查了心血管疾病高危人群的抑郁症状是否与体力活动减少有关。设计对一项强化生活方式干预的随机对照试验的横截面基线数据进行二次分析。设置135初级保健实践在伦敦南部，英国。参与者1742名成年人，49-74岁，86%男性，在未来10年内发生心血管疾病的风险高（>= 20%），通过QRISK2评分确定。主要解释变量是通过患者健康问卷-9 （PHQ-9）测量的抑郁症状。主要结果是用加速度计（ActiGraph GT3X）按工作日和周末分层测量每日步数。结果总样本日步数中位数为6151 (IQR为3510)，差异有统计学意义（P= 10）。在控制了年龄、性别、种族、受教育程度、体重指数（BMI）、吸烟、饮酒、一周中的哪一天和季节等因素后，轻度抑郁症状和中度至重度抑郁症状的个体分别比非抑郁个体少走13.3% （95% CI 18.8%至7.9%）和15.6% （95% CI 23.7%至6.5%）。此外，男性性别、白人种族、高等教育程度、较低BMI、不吸烟、适度饮酒、工作日和夏季与较高的步数独立相关。结论伴有抑郁症状的心血管疾病高危人群PA水平较低。
Objectives Depressive symptoms are common but rarely considered a risk factor for unhealthy lifestyles associated with cardiovascular disease (CVD). This study investigates whether depressive symptoms are associated with reduced physical activity (PA) in individuals at high risk of developing CVD. Design Secondary analysis of the cross-sectional baseline data from a randomised controlled trial of an intensive lifestyle intervention.Setting 135 primary care practices in South London, UK.Participants 1742 adults, 49-74 years, 86% male at high (>= 20%) risk of developing CVD in the next 10 years as defined via QRISK2 score.Outcome measures The main explanatory variable was depressive symptoms measured via the Patient Health Questionnaire-9 (PHQ-9). The main outcome was daily step count measured with an accelerometer (ActiGraph GT3X) stratified by weekdays and weekend days.Results The median daily step count of the total sample was 6151 (IQR 3510) with significant differences (P= 10). Controlling for age, gender, ethnicity, education level, body mass index (BMI), smoking, consumption of alcohol, day of the week and season, individuals with mild depressive symptoms and those with moderate to severe depressive symptoms walked 13.3% (95% CI 18.8% to 7.9%) and 15.6% (95% CI 23.7% to 6.5%) less than non-depressed individuals, respectively. Furthermore, male gender, white ethnicity, higher education level, lower BMI, non-smoking, moderate alcohol intake, weekdays and summer season were independently associated with higher step count.Conclusions People at high risk of CVD with depressive symptoms have lower levels of PA.