Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort
Hydroxyurea lowers transcranial Doppler flow velocities in children with sickle cell anaemia in a Nigerian cohort
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DOI：
10.1002/pbc.25529
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发表时间：
2015-09-01
影响因子：
3.2
通讯作者：
Sodeinde, Olugbemiro
中科院分区：
文献类型：
--
作者：
Lagunju, IkeOluwa;Brown, Biobele J.;Sodeinde, Olugbemiro
研究背景镰状细胞贫血（SCA）是尼日利亚的主要遗传性疾病。大约三分之一的尼日利亚SCA儿童出现170厘米/秒的加速。慢性输血中风预防面临着无数的挑战，在我们的practice.ObjectivesTo评估的有效性，hydroxyurea（HU）在降低血流速度在一个队列的尼日利亚儿童与SCA和速度升高治疗HU.MethodsAn观察性研究进行了一个队列的尼日利亚儿童与SCA和速度升高确定在常规经颅多普勒（TCD）筛查。经颅多普勒速度170 cm/sec者，按我院治疗方案，推荐HU。结果进行了比较后12个月observation.ResultsFifty儿童TCD速度升高进行了研究; 31同意HU治疗和19下降。HU组儿童的平均血流速度从199.7 [17.1]cm/sec下降到165.8 [20.7]cm/sec（P
BackgroundSickle cell anaemia (SCA) is the leading genetic disorder in Nigeria. Elevated velocities 170cm/sec occur in about a third of Nigerian children with SCA. Chronic blood transfusion for stroke prevention is faced with a myriad of challenges in our practice.ObjectivesTo evaluate the effectiveness of hydroxyurea (HU) in reducing flow velocities in a cohort of Nigerian children with SCA and elevated velocities treated with HU.MethodsAn observational study was carried out on a cohort of Nigerian children with SCA and elevated velocities identified on routine transcranial Doppler (TCD) screening. HU was recommended in those with TCD velocities 170cm/sec as stipulated in our hospital protocol. Outcomes were compared after 12months of observation.ResultsFifty children with elevated TCD velocities were studied; 31 consented to HU therapy and 19 declined. Children on HU showed a statistically significant decline in mean velocities from 199.7 [17.1]cm/sec to 165.8 [20.7]cm/sec (P