Highly enantioselective organocatalytic oxidative kinetic resolution of secondary alcohols using chirally modified AZADOs.
Highly enantioselective organocatalytic oxidative kinetic resolution of secondary alcohols using chirally modified AZADOs.
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DOI：
10.1021/ol900441f
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发表时间：
2009-03
期刊：
影响因子：
5.2
通讯作者：
M. Tomizawa;M. Shibuya;Y. Iwabuchi
中科院分区：
文献类型：
--
作者：
M. Tomizawa;M. Shibuya;Y. Iwabuchi
使用不对称有机催化实现了外消旋仲醇的高度对映选择性有机催化氧化动力学拆分（OKR）。一组手性修饰的 2-氮杂金刚烷 N-氧基 (AZADO) 表现出优异的催化活性和高对映选择性，使我们能够获得 k(rel) 值高达 82.2 的光学活性仲醇。
A highly enantioselective organocatalytic oxidative kinetic resolution (OKR) of racemic secondary alcohols has been accomplished using asymmetric organocatalysis. A panel of chirally modified 2-azaadamantane N-oxyls (AZADOs) exhibit superior catalytic activity and high enantioselectivity, allowing us to obtain optically active secondary alcohols with a k(rel) value up to 82.2.