Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.
Spatial Representations of Granule Cells and Mossy Cells of the Dentate Gyrus.
复制标题
DOI：
10.1016/j.neuron.2016.12.026
复制
发表时间：
2017-02-08
期刊：
影响因子：
16.2
通讯作者：
Knierim JJ
中科院分区：
文献类型：
--
作者：
GoodSmith D;Chen X;Wang C;Kim SH;Song H;Burgalossi A;Christian KM;Knierim JJ
海马齿状回中的颗粒细胞被认为是记忆功能所必需的，通过去相关重叠的输入模式（模式分离）。齿状回中的第二种兴奋性细胞，苔藓细胞，与颗粒细胞，CA 3c锥体细胞和局部中间神经元形成复杂的回路，但苔藓细胞对齿状回功能的影响常常被忽视。多个四极记录，支持的triptacellular记录技术，表明颗粒细胞发射非常稀疏，而苔藓细胞在门发射混杂在多个位置和在多个环境。因此，这些细胞类型的活动模式通过不同的计算机制代表不同的环境：颗粒细胞中的稀疏编码和苔藓细胞中发射场位置的变化。GoodSmith等人使用四极和无细胞记录，证明了齿状回和CA 3c内兴奋性细胞类型的不同空间放电和重映射特性，并评估了这些细胞如何支持齿状回-CA 3回路中的模式分离。
Granule cells in the dentate gyrus of the hippocampus are thought to be essential to memory function by decorrelating overlapping input patterns (pattern separation). A second excitatory cell type in the dentate gyrus, the mossy cell, forms an intricate circuit with granule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentate function is often overlooked. Multiple tetrode recordings, supported by juxtacellular recording techniques, showed that granule cells fired very sparsely, whereas mossy cells in the hilus fired promiscuously in multiple locations and in multiple environments. The activity patterns of these cell types thus represent different environments through distinct computational mechanisms: sparse coding in granule cells and changes in firing field locations in mossy cells. Using tetrode and juxtacellular recordings, GoodSmith et al. demonstrate distinct spatial firing and remapping properties of excitatory cell types within the dentate gyrus and CA3c and assess how these cells may support pattern separation in the dentate-CA3 circuit.