DYNAMIC MODIFICATION OF THE VESTIBULO-OCULAR REFLEX BY THE NODULUS AND UVULA
DYNAMIC MODIFICATION OF THE VESTIBULO-OCULAR REFLEX BY THE NODULUS AND UVULA
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DOI：
10.1126/science.3871968
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
RAPHAN, T
中科院分区：
文献类型：
--
作者：
WAESPE, W;COHEN, B;RAPHAN, T
暴露于静止的视觉环境（视觉抑制）下，旋转后眼震或眼震后光动力学慢相眼速衰减的时间常数减小。倾斜头部后也会减少（倾斜抑制）。在这两种类型的抑制中，前庭-眼反射中的一种转储机制被提出以快速释放前庭中枢系统的活动。猴子（猕猴和nemestrina猕猴）在结节和小舌损伤后失去了这种机制。在反复暴露于光动力和前庭刺激下，他们也失去了适应眼球震颤时间常数的能力。周期性交替眼球震颤，被认为是前庭眼反射不稳定的表现，在3只猴子中有2只被观察到。结节和小舌在抑制、调节和稳定前庭眼反射中起着重要的作用。
The time constant of the decay of slow-phase eye velocity of postrotatory nystagmus or optokinetic after-nystagmus is reduced during exposure to a stationary visual surround (visual suppression). It is also reduced after tilting the head (tilt suppression). A dump mechanism in the vestibulo-ocular reflex was proposed to rapidly discharge activity from the central vestibular system during both types of suppression. Monkeys [Macaca mulatta and M. nemestrina] lost this mechanism after lesions of the nodulus and uvula. They also lost the ability to habituate the time constant of nystagmus on repeated exposure to optokinetic and vestibular stimuli. Periodic alternating nystagmus, which is believed to represent an instability in the vestibulo-ocular reflex, was observed in 2 of 3 monkeys. The nodulus and uvula evidently play an important role in suppressing, habituating and stabilizing the vestibulo-ocular reflex.