Mental disorders and cause-specific mortality
Mental disorders and cause-specific mortality
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DOI：
10.1192/bjp.179.6.498
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发表时间：
2001-12-01
影响因子：
10.5
通讯作者：
Lehtinen, V
中科院分区：
文献类型：
--
作者：
Joukamaa, M;Heliövaara, M;Lehtinen, V
背景临床诊断精神障碍对一般人群死亡率的影响尚未确定。目的研究精神障碍对特定死因死亡率的预测。方法采用36个条目的一般健康问卷和现状检查对8000名芬兰成年人进行调查。结果在17年的随访期内，有1597人死亡。在基线上检测到精神障碍的存在与更高的死亡率相关，男性的相对风险为1.6(95%可信区间13-1.8)，女性的相对风险为1.4(95%可信区间1.2-1.6)。与其余样本相比，男性和女性精神分裂症患者在随访期内死亡的相对危险度分别为3.3(95%可信区间2.3~4.9)和2.3(95%可信区间1.3~3.8)。在患有精神分裂症的男性和女性中，死于呼吸系统疾病的风险都增加了，但死于心血管疾病的风险只在患有神经性抑郁症的男性中增加。结论精神分裂症和抑郁症与自然和非自然死亡的风险增加有关。利益声明这项研究由芬兰社会保险机构资助。
Background The impact of clinically diagnosed mental disorders on mortality in the general population has not been established.Aims To examine mental disorders for their prediction of cause-specific mortality.Method Mental disorders were determined using the 36-item version of the General Health Questionnaire and the Present State Examination in a nationally representative sample of 8000 adult Finns.Results During the 17-year follow-up period 1597 deaths occurred. The presence of a mental disorder detected at baseline was associated with an elevated mortality rate,The relative risk in men was 1.6 (95% confidence interval 13-1.8) and in women, 1.4 (95% CI 1.2-1.6). In men and women with schizophrenia the relative risks of death during the follow-up period were 3.3 (95% CI 2.3-4.9) and 2.3 (95% CI 1.3-3.8) respectively, compared with the rest of the sample. In both men and women with schizophrenia the risk of dying of respiratory disease was increased, but the risk of dying of cardiovascular disease was increased only in men with neurotic depression.Conclusions Schizophrenia and depression are associated with an elevated risk of natural and unnatural deaths.Declaration of interest This study was funded by the Social Insurance Institution of Finland.