Objectifying specific and nonspecific effects of acupuncture: a double-blinded randomised trial in osteoarthritis of the knee.
Objectifying specific and nonspecific effects of acupuncture: a double-blinded randomised trial in osteoarthritis of the knee.
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DOI：
10.1155/2013/427265
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Greten HJ
中科院分区：
文献类型：
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作者：
Karner M;Brazkiewicz F;Remppis A;Fischer J;Gerlach O;Stremmel W;Subramanian SV;Greten HJ
导论.针灸最近被证明是有效的治疗膝关节骨性关节炎。然而，争论仍然存在是否观察到的影响是具体的针灸或仅仅是非特异性的针刺后果。因此，本研究的目的是确定不同的针灸治疗方式的疗效。材料和方法。我们在一项具有新型双盲研究设计的前瞻性随机试验中比较了三种不同形式的针灸。116例年龄在35岁至82岁之间的膝关节骨关节炎患者入组3个研究中心。干预措施是个性化的古典/现代半标准化针灸和非特异性针刺。盲法结局评估包括膝关节灵活性和根据WOMAC评分的疼痛变化。结果和讨论。与现代针灸（4.7度; 3.6至5.8）相比，中国古典针灸（10.3度; 95% CI 8.9至11.7）后膝关节灵活性的改善显著更高。所有方法都达到了缓解疼痛的效果，非特异性针刺的患者反应率为48%，现代针刺为64%，古典针刺为73%。结论本试验建立了一种新的研究设计，使针灸研究中的双盲。数据表明，针刺对膝关节活动度有特定作用，并且针刺在缓解疼痛方面有非特异性和特异性作用。
Introduction. Acupuncture was recently shown to be effective in the treatment of knee osteoarthritis. However, controversy persists whether the observed effects are specific to acupuncture or merely nonspecific consequences of needling. Therefore, the objective of this study is to determine the efficacy of different acupuncture treatment modalities. Materials and Methods. We compared between three different forms of acupuncture in a prospective randomised trial with a novel double-blinded study design. One-hundred and sixteen patients aged from 35 to 82 with osteoarthritis of the knee were enrolled in three study centres. Interventions were individualised classical/ modern semistandardised acupuncture and non-specific needling. Blinded outcome assessment comprised knee flexibility and changes in pain according to the WOMAC score. Results and Discussion. Improvement in knee flexibility was significantly higher after classical Chinese acupuncture (10.3 degrees; 95% CI 8.9 to 11.7) as compared to modern acupuncture (4.7 degrees; 3.6 to 5.8). All methods achieved pain relief, with a patient response rate of 48 percent for non-specific needling, 64 percent for modern acupuncture, and 73 percent for classical acupuncture. Conclusion. This trial establishes a novel study design enabling double blinding in acupuncture studies. The data suggest a specific effect of acupuncture in knee mobility and both non-specific and specific effects of needling in pain relief.