Protein misfolding and aggregation
Protein misfolding and aggregation
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DOI：
10.1021/bp060374h
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发表时间：
2007-05-01
影响因子：
2.9
通讯作者：
Kendrick, Brent S.
中科院分区：
文献类型：
--
作者：
Murphy, Regina M.;Kendrick, Brent S.
近年来，对蛋白质错误折叠和聚集问题的兴趣激增，原因有两个：（1）商业生产的治疗性蛋白质的数量和体积急剧上升，以及（2）认识到蛋白质聚集体在退行性疾病中的核心作用。蛋白质聚集的系统研究对实验学家和理论家都提出了重大挑战。由于实验的复杂性，大部分工作保留了经验的味道;蛋白质聚集对蛋白质氨基酸组成、溶剂性质或蛋白质浓度的最微小变化的敏感性;以及缺乏错误折叠和聚集的稳健理论模型。新的实验和计算方法正在开发中，我们预计在不久的将来将取得实质性进展。2006年9月在旧金山弗朗西斯科举行的美国化学学会会议（毕奥分部）上，给出了描述蛋白质错误折叠和聚集的最新进展的几个报告。
Interest in the problem of protein misfolding and aggregation has exploded in recent years for two reasons: ( 1) the sharp rise in the number and volume of therapeutic proteins produced commercially and ( 2) the recognition of the central role of protein aggregates in degenerative diseases. The systematic study of protein aggregation presents major challenges to both the experimentalist and the theoretician. Much of the work retains an empirical flavor due to the experimental complexities; the sensitivity of protein aggregation to the slightest change in protein amino acid composition, solvent properties, or protein concentration; and the lack of robust theoretical models of misfolding and aggregation. Novel experimental and computational approaches are being developed, and we anticipate substantial progress will be made in the near future. Several presentations describing the latest advances in protein misfolding and aggregation were given at the American Chemical Society meeting ( BIOT division) held in September, 2006 in San Francisco.