Effects of long-term selenium supplementation on the incidence of type 2 diabetes - A randomized trial
Effects of long-term selenium supplementation on the incidence of type 2 diabetes - A randomized trial
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DOI：
10.7326/0003-4819-147-4-200708210-00175
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发表时间：
2007-08-21
影响因子：
39.2
通讯作者：
Reid, Mary E.
中科院分区：
文献类型：
--
作者：
Stranges, Saverio;Marshall, James R.;Reid, Mary E.
背景资料：从动物模型的发现表明，硒补充剂改善葡萄糖代谢。目的：检查长期硒补充剂对2型糖尿病发病率的影响。设计：随机、双盲、安慰剂对照试验的次要分析。设置：美国东部低硒消费地区。患者：1202人在皮肤科诊所谁没有2型糖尿病在基线。干预：口服硒，200微克/天，或安慰剂。2型糖尿病的发病率结果如下：在平均7.7年的随访期间（SD，2.7），58名硒接受者和39名安慰剂接受者发生了2型糖尿病（发病率分别为12.6例/1000人-年和8.4例/1000人-年;风险比为1.55 [95%CI，1.03至2.33]）。在按年龄、性别、体重指数和吸烟状况分层的分析中，补充硒对2型糖尿病的发病率没有益处。在基线血浆硒水平的三分位数中发现了一个剂量-反应梯度，在基线血浆硒水平的最高三分位数中，2型糖尿病的风险在统计学上显著增加（风险比，2.70 [CI，1.30至5.61]）。糖尿病的诊断是自我报告的，但在大多数参与者中得到了验证。样本大多是老年人和白色。结论：补充硒似乎不能预防2型糖尿病，它可能会增加疾病的风险。
Background: Findings from animal models suggest that selenium supplementation improves glucose metabolism.Objective: To examine the effect of long-term selenium supplementation on the incidence of type 2 diabetes.Design: Secondary analysis of a randomized, double-blind, placebo-controlled trial.Setting: Areas of low selenium consumption of the eastern United States.Patients: 1202 persons seen in dermatology clinics who did not have type 2 diabetes at baseline.Intervention: Oral administration of selenium, 200 mu g/d, or placebo. Measurements: Incidence of type 2 diabetes. Results: During an average follow-up of 7.7 years (SD, 2.7), type 2 diabetes developed in 58 selenium recipients and 39 placebo recipients (incidence, 12.6 cases per 1000 person-years vs. 8.4 cases per 1000 person-years, respectively; hazard ratio, 1.55 [95% Cl, 1.03 to 2.33]). The lack of benefit of selenium supplementation on the incidence of type 2 diabetes persisted in analyses stratified by age, sex, body mass index, and smoking status. An exposure-response gradient was found across tertiles of baseline plasma selenium level, with a statistically significantly increased risk for type 2 diabetes in the highest tertile of baseline plasma selenium level (hazard ratio, 2.70 [Cl, 1.30 to 5.61]).Limitations: Diabetes was a secondary outcome in the parent trial. Diagnoses of diabetes were self-reported but were validated in most participants. The sample was mostly older and white.Conclusions: Selenium supplementation does not seem to prevent type 2 diabetes, and it may increase risk for the disease.