Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas
Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas
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DOI：
10.1002/hed.20574
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发表时间：
2007-07-01
影响因子：
2.9
通讯作者：
Cortesina, Giorgio
中科院分区：
文献类型：
--
作者：
Cavalot, Andrea;Martone, Tiziana;Cortesina, Giorgio
背景。HER-2/neu基因扩增和蛋白过表达已在多种实体肿瘤中被发现，但其与头颈部鳞状细胞癌（HNSCC）预后的相关性仍存在争议。方法：研究HER-2/ neu癌蛋白在HNSCC中的表达，并寻找其与各种临床病理参数的可能相关性。应用免疫组织化学技术对87例未经治疗的HNSCC患者的档案肿瘤组织中HER-2/neu癌蛋白的表达进行了评估。数据与临床病理参数和患者生存相关。39%的患者膜性HER-2/neu蛋白表达水平较高。多因素分析表明HER-2/neu蛋白表达和pN淋巴结状态是影响无病生存的独立预后因素。HER2/neu过表达及其与生存的关系表明，靶向表皮生长因子受体（EGFR）家族受体的新治疗方法可能为治疗伴有HER2/阴性肿瘤病变的HNSCC患者提供新的途径。(c) 2007 Wiley期刊，Inc。
Background. HER-2/neu gene amplification and protein overexpression have been identified in various solid tumors, but its prognostic relevance in head and neck squamous cell carcinoma (HNSCC) is still controversial.Methods, The study investigated the expression of HER-2/ neu oncoprotein in HNSCC and sought possible correlations to various clinicopathologic parameters. Expression of HER-2/neu oncoprotein was assessed in archival tumor tissues from 87 untreated HNSCC patients by immunohistochemical technique. Data were correlated with both the clinicopathologic parameters and patient survival.Results. A high membranous HER-2/neu protein expression level was found in 39% of patients. Multivariate analysis indicated that HER-2/neu protein expression and pN lymph-node status were independent prognostic factors for disease-free survival.Conclusions. HER2/neu overexpression and its relationship with survival suggest that new therapeutic approaches targeting epidermal growth factor receptor (EGFR) family receptors could provide a new way of treating HNSCC patients with HER2/neupositive neoplastic lesions, (c) 2007 Wiley Periodicals, Inc.