Practical dynamic contrast enhanced MRI in small animal models of cancer: data acquisition, data analysis, and interpretation.
Practical dynamic contrast enhanced MRI in small animal models of cancer: data acquisition, data analysis, and interpretation.
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DOI：
10.3390/pharmaceutics4030442
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发表时间：
2012
期刊：
影响因子：
5.4
通讯作者：
Yankeelov TE
中科院分区：
文献类型：
--
作者：
Barnes SL;Whisenant JG;Loveless ME;Yankeelov TE
动态对比增强磁共振成像（DCE-MRI）包括在注射造影剂之前、期间和之后连续采集图像。DCE-MRI允许对与血管灌注和渗透性以及组织体积分数相关的肿瘤参数进行非侵入性评价，并且经常用于临床前和临床研究。然而，该技术的实验和分析的微妙之处并没有经常在文献中讨论，也不是它的关系，其他常用的定量成像技术。本综述旨在提供有关临床前研究背景下DCE-MRI研究的开发、实施和验证的实用信息（尽管我们经常参考与这些主题相关的临床研究）。
Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) consists of the continuous acquisition of images before, during, and after the injection of a contrast agent. DCE-MRI allows for noninvasive evaluation of tumor parameters related to vascular perfusion and permeability and tissue volume fractions, and is frequently employed in both preclinical and clinical investigations. However, the experimental and analytical subtleties of the technique are not frequently discussed in the literature, nor are its relationships to other commonly used quantitative imaging techniques. This review aims to provide practical information on the development, implementation, and validation of a DCE-MRI study in the context of a preclinical study (though we do frequently refer to clinical studies that are related to these topics).