Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation
Parallel synthesis of 3-aminoimidazo[1,2-a]pyridines and pyrazines by a new three-component condensation
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DOI：
10.1016/s0040-4039(98)00653-4
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发表时间：
1998-05-28
影响因子：
1.8
通讯作者：
Tsai, S
中科院分区：
文献类型：
--
作者：
Blackburn, C;Guan, B;Tsai, S
三氟甲磺酸钪催化2-氨基吡啶、醛和异腈的三组分缩合反应得到3-氨基咪唑并[1，2-a]吡啶衍生物;氨基吡嗪的反应类似。通过平行合成和离子交换树脂纯化以高产率制备的杂环化合物库在氨基上进行进一步反应。(C)1998由Elsevier Science Ltd.出版。保留所有权利。
A three-component condensation reaction between 2-aminopyridine, an aldehyde and an isonitrile catalyzed by scandium triflate affords derivatives of 3-aminoimidazo[1,2-a]pyridine; aminopyrazine reacts similarly. A library of heterocycles, prepared in high yield by parallel synthesis and purification on an ion-exchange resin, was subjected to further reactions at the amino group. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.