Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men
Association of UCP2 and UCP3 polymorphisms with heart rate variability in Japanese men
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DOI：
10.1097/hjh.0b013e32831ac967
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发表时间：
2009-02
影响因子：
4.9
通讯作者：
Tetsuro Matsunaga;N. Gu;H. Yamazaki;Mariko Tsuda;T. Adachi;K. Yasuda;T. Moritani;K. Tsuda;Masahiko Nonaka;Tohru Nishiyama
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文献类型：
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作者：
Tetsuro Matsunaga;N. Gu;H. Yamazaki;Mariko Tsuda;T. Adachi;K. Yasuda;T. Moritani;K. Tsuda;Masahiko Nonaka;Tohru Nishiyama
目的线粒体解偶联蛋白UCP 2和UCP 3参与能量代谢和活性氧的调节，与植物神经系统功能密切相关。心率变异性（HRV）反映了心脏的自主神经调节功能，已被用于评价高血压和心血管疾病的自主神经功能障碍。我们研究了日本健康年轻男性UCP 2和UCP 3基因多态性与HRV之间的关系。方法对255例UCP 2基因外显子8的45 bp插入/缺失多态性和UCP 3基因启动子区的− 55 C/T多态性进行基因分型。心脏自主神经功能通过仰卧位和站立位心率变异性的功率谱分析来评价。心率变异性的低频（0.15 Hz）分量通过频域分析进行量化。结果UCP 2 45 bp插入/缺失多态性I/I基因型与仰卧位静息时血压和HRV交感神经指数（低频百分比和低频：高频比值）相对较高相关。对于UCP 3的− 55 C/T多态性，与C/C基因型携带者相比，携带− 55 T等位基因的个体在站立时具有显著较低的HRV交感神经指数，但较高的HRV副交感神经指数（高频和高频百分比）。UCP 2和UCP 3多态性与高血压、糖尿病和肥胖的三级家族史显著相关。此外，UCP 2 45 bp I等位基因− UCP 3 − 55 C/C组合基因型的携带者在站立时的HRV交感神经指数最低，HRV副交感神经指数最高。结论UCP 2和UCP 3基因多态性与年轻健康人群的心率变异性相关，提示UCP 2/UCP 3基因多态性与心血管自主调节功能密切相关。
Objectives The mitochondrial uncoupling proteins UCP2 and UCP3 are implicated in energy metabolism and regulation of reactive oxygen species, which are closely involved in autonomic nervous system function. Heart rate variability (HRV) reflects cardiac autonomic regulation and has been used to evaluate dysfunction of the autonomic nervous system in hypertension and cardiovascular diseases. We examined the association between polymorphisms in the UCP2 and UCP3 genes and HRV in healthy young Japanese men. Methods The 45 bp insertion/deletion polymorphism in exon8 of UCP2 and the −55C/T polymorphism in the UCP3 promoter region were genotyped (n = 255). Cardiac autonomic function was evaluated by power spectral analysis of HRV during supine rest and in a standing position. Low-frequency (0.15 Hz) components of HRV were quantified by frequency domain analysis. Results The I/I genotype of the UCP2 45 bp insertion/deletion polymorphism was associated with relatively higher blood pressure and HRV sympathetic indices (low frequency percentage and low frequency:high frequency ratio) at supine rest. For the −55C/T polymorphism of UCP3, individuals carrying the −55T allele had significantly lower HRV sympathetic indices, but higher HRV parasympathetic indices (high frequency and high frequency percentage), than carriers of the C/C genotype at standing. Both UCP2 and UCP3 polymorphisms were significantly associated with a third-degree family history of hypertension, diabetes, and obesity. Additionally, carriers of the UCP2 45 bp I allele −UCP3 −55C/C combined genotype had the lowest HRV sympathetic and the highest HRV parasympathetic indices at standing among the combined genotypes. Conclusion UCP2 and UCP3 polymorphisms were associated with HRV in young and healthy states, suggesting a significant relationship between autonomic cardiovascular regulation and UCP2/UCP3 polymorphisms.