THE NATURE OF ANDROGEN ACTION ON MALE-SEXUALITY - A COMBINED LABORATORY-SELF-REPORT STUDY ON HYPOGONADAL MEN
THE NATURE OF ANDROGEN ACTION ON MALE-SEXUALITY - A COMBINED LABORATORY-SELF-REPORT STUDY ON HYPOGONADAL MEN
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DOI：
10.1210/jcem-57-3-557
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发表时间：
1983-01-01
影响因子：
5.8
通讯作者：
DAVIDSON, JM
中科院分区：
文献类型：
--
作者：
KWAN, M;GREENLEAF, WJ;DAVIDSON, JM
研究了6例性腺功能减退男性的性功能及庚酸睾酮的作用，目的是阐明雄激素对男性性功能的影响。为了获得这些组件的详细图片，前瞻性的自我报告数据（从每日日志）的性活动和感觉，记录所有夜间阴茎肿胀，和实验室心理生理学数据进行了评估。采用交叉设计的双盲安慰剂实验比较安慰剂与200 mg和400 mg剂量庚酸睾酮的效果。性功能减退患者对色情电影和幻想的勃起反应并不低于正常男性，事实上，在某些参数上，特别是在暴露于电影或幻想后的消肿时间延长。三名坚持每日记录的受试者在服用睾酮后，性行为和性感觉、性高潮和自发勃起的频率增加。在未治疗的性腺功能减退男性中，夜间阴茎肿胀和自发性日间勃起减少，在睾酮治疗后显著增加，但实验室测试的对电影和幻想的勃起反应不受睾酮的影响。雄激素对男性性行为的主要作用涉及性欲因素（即，性动机/兴趣）。虽然在实验室中引起的刺激性勃起在性腺功能减退的男性中并没有减少，但自发（睡眠或清醒）勃起显然依赖于睾酮。
Sexual function and the effects thereon of testosterone enanthate were studied in 6 hypogonadal men with the objective of delineating the specific components of male sexuality affected by androgen. To obtain a detailed picture of these components, prospective self-report data (from daily logs) of sexual activity and feelings, recordings of all night penile tumescence, and laboratory psychophysiological data were assessed. Double-blind placebo experiments with cross-over design were used to compare the effects of placebo and 200- and 400-mg doses of testosterone enanthate. Erectile responses to erotic film and fantasy were not lower in the hypogonadal patients than in normal men and, in fact, were higher on some parameters, especially prolongation of detumescence time after exposure to film or fantasy. Three subjects who kept consistent daily logs had increased frequencies of sexual acts and feelings, orgasms, and spontaneous erections after testosterone administration. Nocturnal penile tumescence and spontaneous daytime erections were reduced in untreated hypogonadal men and were significantly increased after testosterone treatment, but the laboratory-tested erectile responses to film and fantasy were not affected by testosterone. The major androgen action on male sexuality involves libido factors (i.e., sexual motivation/interest). Though stimulus-bound erections elicited in the laboratory were not reduced in hypogonadal men, spontaneous (sleep or waking) erections were clearly testosterone dependent.