The effects of estrogens on regional adipose tissue cellularity in the rat.
The effects of estrogens on regional adipose tissue cellularity in the rat.
复制标题
雌激素对大鼠局部脂肪组织细胞结构的影响。
DOI：
10.1111/j.1748-1716.1976.tb10178.x
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
Marcin Krotkiewski
中科院分区：
文献类型：
--
作者：
Marcin Krotkiewski
研究了高剂量和低剂量雌激素对雌性大鼠脂肪组织细胞结构和代谢的影响，并与完全饥饿的影响进行了比较。雌性大鼠完全饥饿导致局部脂肪细胞大小减少，在不同的脂肪组织区域，这与初级脂肪细胞的大小成正比。因此，在脂肪组织的子宫旁储库中观察到最大的脂肪细胞尺寸减小，主要是最小的脂肪细胞。高剂量雌激素（Estradurin-120 μ g/kg/月）导致10周治疗后体重和脂肪组织重量下降。与饥饿效应相反，在皮下贮库中观察到最大的脂肪细胞尺寸减小，主要是最小的脂肪细胞。较低的雌激素剂量（60 μ g/kg/月）导致，治疗4周后，脂肪组织的重量增加。脂肪细胞的大小增加最多的子宫旁组织库脂肪组织区域主要是最大的脂肪细胞。这与胰岛素治疗和过度喂养后的情况相反，胰岛素治疗和过度喂养在具有最小脂肪细胞的区域中产生最大的尺寸增加，并且可以解释为雌激素对脂肪细胞作用的区域特异性的证据。
The effects of high and low dose estrogen administration on adipose tissue cellularity and metabolism were investigated and compared with the effect of total starvation in female rats. Total starvation in female rats resulted in local fat cell size decrease which was, in different adipose tissue regions, directly proportional to the primary fat cell size. Thus, the largest fat cell size decrease was observed in the parametrial depot of adipose tissue, with primarily the smallest adipocytes. High doses of estrogen (Estradurin-120 mug/kg/month) resulted in a body and adipose tissue weight decrease after 10 weeks treatment. Contrary to the starvation effect the greatest fat cell size decrease was observed in the subcutaneous depot with primarily the smallest adipocytes. Lower estrogen dose (60 mug/kg/month) resulted, after 4 weeks treatment, in weight increase of adipose tissue. Fat cell size increased most in the parametrial depot-an adipose tissue region with primarily the biggest adipocytes. This is in contrast to the situation after insulin treatment and overfeeding which produce the largest size increase in the region with the smallest fat cells, and can be interpreted as evidence for regional specificity of the estrogen effect on fat cells.