ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation
ITGB4 deficiency induces senescence of airway epithelial cells through p53 activation
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ITGB4缺陷通过p53激活诱导气道上皮细胞衰老
DOI：
10.1111/febs.14749
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发表时间：
2019-02
期刊：
影响因子：
5.4
通讯作者：
Liu Chi
中科院分区：
文献类型：
--
作者：
Yuan Lin;Du Xizi;Tang Sha;Wu Shuangyan;Wang Leyuan;Xiang Yang;Qu Xiangping;Liu Huijun;Qin Xiaoqun;Liu Chi
Aging is characterized by a progressive loss of physiological integrity, leading to impaired organ function and, ultimately, increased vulnerability to death. Many complex diseases are related to aging, including asthma. In the lung, the airway epithelium serves as the first barrier to prevent the access of inspired external stimuli and dictates the initial stress responses. Notably, in the airway mucosa of asthma patients, an increase in senescent airway epithelial cells has been detected. Although it has been speculated that the senescence of airway epithelial cells could increase asthma susceptibility and aggravate asthma severity, the role of cell senescence in the development of asthma remains unclear. Integrin β4 (ITGB4) is a structural adhesion molecule with complex physiological functions that is downregulated in airway epithelial cells of asthma patients. This study demonstrates that the expression of ITGB4 in airway epithelial cells is downregulated significantly under oxidative stress or upon inflammatory stimulation. Moreover, we show that ITGB4 deficiency induces the senescence of airway epithelial cells through the activation of the p53 pathway both in vitro and in vivo. Together, our results demonstrate that airway epithelial senescence induced by ITGB4 deficiency after oxidative stress or inflammatory stimulation may be involved in the pathogenesis of asthma. Understanding the contribution of ITGB4 deficiency to the senescence of airway epithelial cells in asthma patients may provide new therapeutic approaches for the treatment of asthma.
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影响因子：
3.5
作者：
Xia Liu;D. Yin;Yun Zhang;J. Zhao;Shang Li Zhang;J. Miao
通讯作者：
Xia Liu;D. Yin;Yun Zhang;J. Zhao;Shang Li Zhang;J. Miao
DOI：
10.4168/aair.2017.9.1.25
发表时间：
2017-01
期刊：
Allergy, asthma & immunology research
影响因子：
--
作者：
Lee HY;Kim IK;Yoon HK;Kwon SS;Rhee CK;Lee SY
通讯作者：
Lee SY
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
DOI：
10.4049/jimmunol.0803468
发表时间：
2009-04
期刊：
The Journal of Immunology
影响因子：
--
作者：
Ming Yang;Rakesh K. Kumar;P. Foster
通讯作者：
Ming Yang;Rakesh K. Kumar;P. Foster
影响因子：
14.2
作者：
Xiao, Chang;Puddicombe, Sarah M.;Davies, Donna E.
通讯作者：
Davies, Donna E.