Copper, iron and zinc in Alzheimer's disease senile plaques
Copper, iron and zinc in Alzheimer's disease senile plaques
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DOI：
10.1016/s0022-510x(98)00092-6
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发表时间：
1998-06-11
影响因子：
4.4
通讯作者：
Markesbery, WR
中科院分区：
文献类型：
--
作者：
Lovell, MA;Robertson, JD;Markesbery, WR
采用微粒子诱导x射线发射（micro- pixe）技术测定了9例阿尔茨海默病（AD）患者老年斑（SP）边缘和核心、杏仁核神经pil及5例神经正常对照者杏仁核神经pil中铜（Cu）、铁（Fe）和锌（Zn）的浓度。SP边缘值和核心值的比较显示Cu、Fe和Zn水平之间无显著差异。与阿尔茨海默病相比，阿尔茨海默病的SP边缘和核心中锌和铁含量显著升高(P
Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease (AD) patients and in the neuropil of the amygdala of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE). Comparison of SP rim and core values revealed no significant differences between levels of Cu, Fe or Zn. Zinc and Fe in SP rims and cores were significantly elevated in AD compared with AD neuropil (P