PLASMA TUMOR NECROSIS FACTOR AND MORTALITY IN CRITICALLY ILL SEPTIC PATIENTS
PLASMA TUMOR NECROSIS FACTOR AND MORTALITY IN CRITICALLY ILL SEPTIC PATIENTS
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DOI：
10.1097/00003246-198906000-00001
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发表时间：
1989-06-01
影响因子：
8.8
通讯作者：
VANDERLINDEN, CJ
中科院分区：
文献类型：
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作者：
DEBETS, JMH;KAMPMEIJER, R;VANDERLINDEN, CJ
肿瘤坏死因子（TNF） cachectin被认为是脓毒症期间休克和多器官衰竭（MOF）的重要宿主介质。使用敏感的酶联免疫吸附试验，我们测量了43名患有多种疾病的脓毒症患者的血浆TNF水平。在诊断出败血症的当天进行测量。11例患者可检测到TNF血浆水平在10至100 pg/ml之间（TNF阳性组）；32例患者循环TNF未检出（TNF阴性组）。两组在年龄、基础疾病、阳性菌血症百分比和细菌学特征、败血症评分和MOF程度方面无显著差异。11例tnf阳性患者中有8例（73%）在ICU住院期间死于败血症，而32例tnf阴性患者中有11例（34%）死于败血症（p< 0.05）。05）. 该研究表明，25%的脓毒症患者伴有可检测到的循环TNF，这些患者的死亡率是TNF阴性患者的两倍。（急救医学1989；17:489）
Tumor necrosis factor (TNF) cachectin has been implicated as an important host mediator responsible for shock and multiple organ failure (MOF) observed during sepsis. Using a sensitive enzyme-linked immunosorbent assay, we measured plasma TNF levels in 43 septic patients suffering from a broad range of diseases. Measurements were taken on the day that sepsis was diagnosed. Eleven patients had detectable TNF plasma levels ranging from 10 to 100 pg/ml (TNF-positive group); in 32 patients circulating TNF could not be detected (TNF-negative group). The groups did not differ significantly as to age, underlying disease, percentage positive bacteremia and bacteriologic profile, sepsis score, and extent of MOF. Eight (73%) of 11 TNF-positive patients died from sepsis during ICU stay, vs. 11 (34%) of 32 TNF-negative patients (p<. 05). This study demonstrates that sepsis is accompanied by detectable circulating TNF in 25% of the cases, and for these patients mortality is twice that for comparable TNF-negative patients.(Crit Care Med 1989; 17: 489)