Risk factors for helminth infections in a rural and a pen-urban setting of the Dongting Lake area, People's Republic of China
Risk factors for helminth infections in a rural and a pen-urban setting of the Dongting Lake area, People's Republic of China
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DOI：
10.1016/j.ijpara.2011.07.006
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发表时间：
2011-09-01
影响因子：
4
通讯作者：
McManus, Donald P.
中科院分区：
文献类型：
--
作者：
Balen, Julie;Raso, Giovanna;McManus, Donald P.
日本血吸虫病和土源性蠕虫病是中华人民共和国的地方性寄生虫病。由于很少有研究报道多种蠕虫感染的分布和相互作用，我们于2006年11月和12月在湖南省洞庭湖区的一个农村和一个城市周边地区进行了一项比较研究，以确定单一和多个物种感染的程度，感染的潜在危险因素，以及与临床表现和自报发病率的关系。在每个家庭中，收集粪便样本，并进行加藤-卡茨法鉴定日本血吸虫，蛔虫，钩虫和鞭虫感染。在家庭和个体受试者层面进行了临床检查和问卷调查。获得了两个环境中1 298名居民的完整寄生虫学、临床和问卷调查数据。单次感染的总患病率为100%。japonicum、日本刺蛾A.蛔虫、钩虫和T.鞭毛虫感染率分别为6.5%、5.5%、3.0%和0.8%，以轻度感染为主。我们发现财富和感染沙门氏菌之间存在显著的负相关。japonicum和A.蚯蚓。临床表现以脾肿大、肝肿大和贫血为主（分别为9.0%、3.7%和10.9%），后两者与血吸虫病有显著相关性（P < 0.05）。自我报告的症状在女性中更常见，但在两种性别中，仅依靠自发回忆时，有相当大的报告不足。我们的研究结果可能会指导湖南省和中国其他地区的寄生虫病控制计划的设计和目标，更公平，全面和综合。(C)2011年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
Schistosomiasis japonica and soil-transmitted helminthiasis are endemic parasitic diseases in the People's Republic of China (PR China). As very few studies have reported on the distribution and interaction of multiple species helminth infections, we carried out a comparative study of households in a rural village and a pen-urban setting in the Dongting Lake area of Hunan province in November and December 2006 to determine the extent of single and multiple species infections, the underlying risk factors for infection, and the relationships with clinical manifestations and self-reported morbidity. In each household, stool samples were collected and subjected to the Kato-Katz method for identifying Schistosoma japonicum, Ascaris lumbricoides, hookworm and Trichuris trichiura infections. Clinical examinations were performed and questionnaire surveys conducted at both household and individual subject levels. Complete parasitological, clinical and questionnaire data were obtained for 1,298 inhabitants of the two settings. The overall prevalences of single infections of S. japonicum, A. lumbricoides, hookworm and T. trichiura were 6.5%, 5.5%, 3.0% and 0.8%, respectively; the majority of the infections were of light intensity. We found significant negative associations between wealth and infections with S. japonicum and A. lumbricoides. Clinical manifestations of splenomegaly, hepatomegaly and anaemia were prevalent (9.0%, 3.7% and 10.9%, respectively), the latter two being significantly (P < 0.05) associated with schistosomiasis. Self-reported symptoms were more common among females but there was considerable under-reporting in both sexes when relying only on spontaneous recall. Our findings may guide the design and targeting of a more equitable, comprehensive and integrated parasitic disease control programme in Hunan province and in other areas of PR China. (C) 2011 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.