Osteosarcoma of bone.
Osteosarcoma of bone.
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DOI：
10.1007/s007760050055
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Unni, K K
中科院分区：
文献类型：
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作者：
Unni, K K
骨肉瘤的定义要求恶性骨肿瘤产生类骨质或骨基质。以此为基本定义，骨肉瘤可根据临床、X线和病理特征分为几种临床病理实体。肿瘤可大致分为骨内发生的肿瘤和骨表面发生的肿瘤。大多数骨内骨肉瘤是发生在儿童和青少年的高度恶性肿瘤。少数发生在老年患者中，它们可能与先前存在的疾病有关，如佩吉特病或放射。病变部位对预后有重要意义。颌骨骨肉瘤预后特别好，而累及颅骨的同类肿瘤预后非常差。大多数骨表面的骨肉瘤分化良好或中等，预后良好。
The definition of osteosarcoma requires that a malignant tumor of bone produce osteoid or bony matrix. With this as a basic definition, osteosarcoma of bone can be divided into several clinicopathologic entities based on clinical, roentgenographic, and pathologic features. The tumors can be broadly divided into those arising within the bone and those arising on the surface of bone. Most intraosseous osteosarcomas are high-grade malignant tumors that occur in children and adolescents. A small number occur in older patients, and they may be related to a preexisting condition, such as Paget's disease or radiation. The site of the lesion has prognostic importance. Osteosarcoma of the jaws is associated with an especially good prognosis, whereas the same kind of tumor involving the skull has a very poor prognosis. Most osteosarcomas of the surface of bone are well or moderately differentiated and are associated with an excellent prognosis.