The effects and toxicity of cathinones from the users' perspectives: A qualitative study
The effects and toxicity of cathinones from the users' perspectives: A qualitative study
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DOI：
10.1002/hup.2610
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发表时间：
2017-05-01
影响因子：
1.7
通讯作者：
Osselton, David
中科院分区：
文献类型：
--
作者：
Assi, Sulaf;Gulyamova, Nargilya;Osselton, David
目的探讨用户对卡卡因疗效和毒性的看法。方法系统检索互联网论坛，检索出303条与研究目标相关的主题。这些线索通过传统的内容分析进行分析，其中概念是从代码和主题发展而来的。结果研究确定了与卡西酮的使用、效果和毒性有关的3个主题。第一个主题考虑了卡西酮的摄入方式与所取衍生物(主要是甲氧麻黄酮、3-甲基甲卡西酮和亚甲基二氧基吡咯丙酮)、给药途径(眼球、注气、吸烟、静脉注射、口服、直肠和舌下)、多种药物的使用以及卡西酮衍生物的纯度。第二个主题描述了卡西诺酮的主要作用，即增加能量、兴奋和致病。据报道，毒性作用涉及神经系统(焦虑、幻觉、紧张和偏执)、心血管系统(心绞痛、心肌梗死和心动过速)、皮肤(变色、瘙痒和过敏)和肾脏系统(排尿困难)。药物与药物的相互作用也被报道，包括卡西酮、兴奋剂、镇静剂和迷幻剂之间的多药使用。结论互联网论坛提供了关于卡西酮的疗效和毒性的有用信息来源，在评估药物的安全性时可以考虑在内。
ObjectiveThe objective of this study is to explore the users' perspectives regarding the effects and toxicity of cathinones.MethodsA systematic search of Internet discussion forums yielded 303 threads relevant to the research objectives. The threads were analysed by conventional content analysis where concepts were developed from codes and themes.ResultsThe study identified 3 main themes in relation to cathinone use, effects, and toxicity. The first theme considered the modalities of intake of cathinones in relation to the derivative taken (mainly mephedrone, 3-methylmethcathinone, and methylenedioxypyrovalerone), route of administration (eyeballing, insufflation, smoking, intravenous, oral, rectal, and sublingual), multidrug use, and purity of the cathinone derivative. The second theme characterised the main effects of cathinones, that is, increased energy, euphoria, and empathogenic. Toxic effects were reported regarding the nervous system (anxiety, hallucinations, nervousness, and paranoia), cardiovascular system (angina, myocardial infarction, and tachycardia), skin (discolouration, itching, and allergy), and renal system (difficulty in urination). Drug-drug interactions were also reported including multiple drug use between cathinones, stimulants, depressants, and hallucinogens.ConclusionsThe Internet discussion forums provide useful sources of information regarding the effects and toxicity of cathinones, which can be taken into account when assessing the safety of drugs.