Self-Assembly Strategy for the Preparation of Polymer-Based Nanoparticles for Drug and Gene Delivery
Self-Assembly Strategy for the Preparation of Polymer-Based Nanoparticles for Drug and Gene Delivery
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DOI：
10.1002/mabi.201000427
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发表时间：
2011-05-12
影响因子：
4.6
通讯作者：
Zhuo, Ren-Xi
中科院分区：
文献类型：
--
作者：
Chen, Si;Cheng, Si-Xue;Zhuo, Ren-Xi
纳米颗粒药物递送系统由于其可注射性、被动靶向和主动靶向的可能性以及实现刺激定制递送的独特优势而变得越来越重要。分子自组装是制备聚合物基纳米粒子的一种强有力的方法，它涉及到各种驱动力，如疏水相互作用、静电相互作用、立体络合作用、主/客体相互作用和氢键。通过微调这些相互作用的一种或多种类型，可以制造具有广泛结构和功能的自组装。本文讨论了制备聚合物基纳米颗粒递送系统的不同自组装策略的最新进展。
Nanoparticulate drug-delivery systems have attained much importance because of their injectable property, the possibility to achieve passive targeting and active targeting, and unique advantages to realize stimuli tailored delivery. Molecular self-assembly is a powerful method for fabricating polymer-based nanoparticles, which involves various driving forces, such as hydrophobic interactions, electrostatic interactions, stereo-complexation, host/guest interactions and hydrogen bonding. By fine tuning one or many types of these interactions, self-assemblies with a wide range of structures and functions could be fabricated. In this article, recent developments in different self-assembly strategies for the preparation of polymer-based nanoparticulate delivery systems are discussed.