Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects
Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects
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DOI：
10.1152/ajpgi.00163.2002
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发表时间：
2003-04-01
影响因子：
4.5
通讯作者：
Jones, KL
中科院分区：
文献类型：
--
作者：
Berry, MK;Russo, A;Jones, KL
胃排空是餐后的决定因素。对口服碳水化合物的血糖和心血管反应。我们评估了健康老年受试者固体膳食对胃排空的影响以及对口服葡萄糖的血糖和心血管反应。对 10 名年龄为 72.1 +/- 1.9 岁的受试者进行了研究。每个受试者在摄入 50 克葡萄糖饮料（300 毫升）和（混合餐）或不含（仅液体）固体餐（300 克碎牛肉）后测量胃排空、血糖、血清胰岛素、血压和心率。与仅 5 分钟液体相比，混合餐后液体的胃排空最初稍快一些 (P < 0.05)（92.0 +/- 1.5 vs. 96.0 +/- 1.3%），120 分钟后则慢得多（P < 0.05）。混合餐后，达到血糖峰值的时间较短（39.0 +/- 4.0 vs. 67.5 +/- 10.3 分钟；P < 0.01），并且血糖随后较低（P < 0.01）。混合餐后血清胰岛素增加幅度更大（P<0.001）。前 30 分钟血压下降（P < 0.05），两餐之间没有差异。两餐后心率增加（P < 0.005），混合餐后心率增加更大（P < 0.05）。非碳水化合物固体膳食的存在对营养液的早期和随后排空有不同的影响，这会影响餐后血糖和增加心率。
Gastric emptying is a determinant of the postprandial. glycemic and cardiovascular responses to oral carbohydrate. We evaluated the effects of a solid meal on gastric emptying and the glycemic and cardiovascular responses to oral glucose in healthy older subjects. Ten subjects aged 72.1 +/- 1.9 yr were studied. Each subject had measurements of gastric emptying, blood glucose, serum insulin, blood pressure, and heart rate after ingestion of a 50-g glucose drink (300 ml) with (mixed meal) or without (liquid only) a solid meal (300 g ground beef). Gastric emptying of liquid was initially slightly more rapid (P < 0.05) after the mixed meal compared with liquid only at 5 min (92.0 +/- 1.5 vs. 96.0 +/- 1.3%) and much slower (P < 0.05) after 120 min. The time to peak blood glucose was less (39.0 +/- 4.0 vs. 67.5 +/- 10.3 min; P < 0.01) and blood glucose subsequently lower (P < 0.01) after the mixed meal. The increase in serum insulin was greater (P < 0.001) after the mixed meal. Blood pressure fell (P < 0.05) in the first 30 min, with no difference between the two meals. Increase in heart rate after both meals (P < 0.005), was greater (P < 0.05) after the mixed meal. The presence of a noncarbohydrate solid meal had discrepant effects on early and subsequent emptying of a nutrient liquid, which affects postprandial glycemia and increased heart rate.