Electroacupuncture versus Moxibustion for Irritable Bowel Syndrome: A Randomized, Parallel-Controlled Trial.
Electroacupuncture versus Moxibustion for Irritable Bowel Syndrome: A Randomized, Parallel-Controlled Trial.
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DOI：
10.1155/2015/361786
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Wu HG
中科院分区：
文献类型：
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作者：
Shi Y;Chen YH;Yin XJ;Wang AQ;Chen XK;Lu JH;Ji R;Bao CH;Sun J;Zhao JM;Wu HG
目的：比较电针（EA）和温和灸（Mox）对肠易激综合征（IBS）患者的影响。
方法：82例IBS患者随机分为电针组（n = 41）和温和灸组（n = 41），并接受相应干预4周。治疗前后，采用肠易激综合征视觉模拟量表（VAS - IBS）评估胃肠道症状和心理健康状况；检测乙状结肠黏膜组织中5 - 羟色胺（5 - 羟色胺，5 - HT）、5 - HT3受体（5 - HT3R）和5 - HT4受体（5 - HT4R）的表达。
结果：电针和温和灸均可显著改善VAS - IBS总分（P < 0.05），且电针在改善便秘症状方面更有效，温和灸在改善腹泻症状方面更有效。两组治疗后5 - HT、5 - HT3R和5 - HT4R的异常表达均显著改善（均P < 0.05），电针在调节便秘型IBS患者中异常降低的5 - HT4R表达方面优于温和灸（P < 0.05）。
结论：电针和温和灸均能有效改善IBS症状，并调节结肠组织中5 - HT、5 - HT3R和5 - HT4R的异常表达。
Objective. To compare the impacts of electroacupuncture (EA) and mild moxibustion (Mox) on patients with irritable bowel syndrome (IBS). Method. Eighty-two IBS patients were randomly allocated into EA group (n = 41) and Mox group (n = 41) and received corresponding interventions for four weeks. Before and after the treatment, the Visual Analogue Scale for Irritable Bowel Syndrome (VAS-IBS) was used to evaluate the gastrointestinal symptoms and mental well-being; and the expression of serotonin (5-hydroxytryptamine, 5-HT), 5-HT3 receptor (5-HT3R), and 5-HT4 receptor (5-HT4R) in sigmoid mucosal tissue were detected. Results. Both EA and Mox can radically improve the total VAS-IBS score (P < 0.05), and EA was found to be more effective in ameliorating the symptom of constipation, while Mox was found to be more effective in ameliorating the symptom of diarrhoea. The abnormal expressions of 5-HT, 5-HT3R, and 5-HT4R in both groups were significantly improved after the treatments (all P < 0.05), and EA was superior to Mox in regulating the abnormally decreased 5-HT4R expression in IBS patients with constipation (P < 0.05). Conclusion. Electroacupuncture and mild moxibustion were both effective in improving IBS symptoms and modulate abnormal expressions of 5-HT, 5-HT3R, and 5-HT4R in the colonic tissue.