HIGH-INCIDENCE OF ENDOGENOUS-DEPRESSION IN MIGRAINE - CONFIRMATION BY TYRAMINE TEST
HIGH-INCIDENCE OF ENDOGENOUS-DEPRESSION IN MIGRAINE - CONFIRMATION BY TYRAMINE TEST
复制标题
DOI：
10.1136/jnnp.53.7.573
复制
发表时间：
1990-07-01
影响因子：
11
通讯作者：
SANDLER, M
中科院分区：
文献类型：
--
作者：
JARMAN, J;FERNANDEZ, M;SANDLER, M
用情感障碍量表和精神分裂症终生版对40名到专科诊所就诊的偏头痛患者进行访谈。根据研究诊断标准，16人(40%)有严重抑郁症病史，其中15人为内源性抑郁症。酪胺试验是先前建立的内源性抑郁的特征标记，它显示偏头痛组作为一个整体与14名正常对照组相比，其值显著低，几乎完全是由于内源性抑郁亚组的低值；饮食敏感型和非饮食敏感型偏头痛患者之间没有差异。因此，偏头痛患者的抑郁似乎不太可能是偏头痛本身的继发性症状。相当一部分偏头痛患者可能具有内源性抑郁的先天易感性。
Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia-Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.