Fatty acids and early human development
Fatty acids and early human development
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DOI：
10.1016/j.earlhumdev.2007.09.004
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发表时间：
2007-12-01
影响因子：
2.5
通讯作者：
Innis, Sheila M.
中科院分区：
文献类型：
--
作者：
Innis, Sheila M.
脂肪酸通过其在膜脂类中的作用，作为调节基因表达的受体和转录因子的配体，在细胞通讯中的作用，以及通过与蛋白质的直接相互作用，在生长和发育中发挥核心作用。胎儿和儿童发育期间的不利脂肪酸供应会改变细胞膜磷脂和储存甘油三酯的脂肪酸组成，从而有可能扰乱细胞环境，并影响程序的结构和功能。孕期和哺乳期的母体脂肪酸营养决定了必需的n-6和n-3以及非必需的反式脂肪酸通过胎盘和母乳的转移。母亲的二十二碳六烯酸(DHA)状况不佳会增加DHA不足以支持大脑和视网膜发育的风险，从而延迟或限制神经和视觉系统的发育。最近饮食脂肪酸的变化对母婴脂肪酸转移的影响，包括母乳的组成，研究得还不够充分。(C)2007爱思唯尔爱尔兰有限公司。保留所有权利。
Fatty acids play central roles in growth and development through their roles in membrane lipids, as ligands for receptors and transcription factors that regulate gene expression, precursor for eicosanoids, in cellular communication, and through direct interactions with proteins. Adverse fatty acid supplies during fetal and child development alter the fatty acid composition of membrane phospholipids and storage triglycerides with the potential to disrupt cellular environments, and program structure and function. Maternal fatty acid nutrition during pregnancy and lactation determines the transfer of essential n-6 and n-3, and non-essential trans fatty acids via the placenta and through human milk. Poor maternal docosahexaenoic acid (DHA) status increases risk of inadequate DHA to support brain and retinal development, delaying or limiting neural and visual system development. The implications of recent changes in the dietary fatty acids on maternal to infant fatty acid transfer, including the composition of human milk has been insufficiently studied. (c) 2007 Elsevier Ireland Ltd. All rights reserved.