Immune mechanisms underlying host susceptibility to infection with group A streptococci
Immune mechanisms underlying host susceptibility to infection with group A streptococci
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DOI：
10.1086/368390
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发表时间：
2003-03-01
影响因子：
6.4
通讯作者：
Medina, E
中科院分区：
文献类型：
--
作者：
Goldmann, O;Chhatwal, GS;Medina, E
不同品系的小鼠对 A 族链球菌 (GAS) 感染的易感性存在显着差异，其中 BALB/c 小鼠比 C3H/HeN 小鼠的抵抗力要强得多。在这项研究中，我们研究了这两种小鼠品系宿主对 GAS 感染的抵抗/易感性的机制。 BALB/c 小鼠 GAS 感染的消退与细菌增殖的有效控制和适度的炎症反应相关。相比之下，C3H/HeN 小鼠无法控制细菌生长，并且在感染时产生强烈的炎症反应，导致广泛的组织破坏、器官衰竭和死亡。此外，在对 GAS 产品的体外刺激的反应中，C3H/HeN 小鼠的脾细胞比 BALB/c 小鼠的脾细胞具有更强的增殖活性和更多的 IFN-γ 产生。因此，未能限制细菌生长、随之而来的高水平细菌产物以及产生高水平炎症介质的遗传倾向似乎是 C3H/HeN 小鼠对 GAS 感染易感性的原因。
Different strains of mice differ markedly in their susceptibility to group A streptococci (GAS) infection, with BALB/c mice being much more resistant than C3H/HeN mice. In this study, we examined the mechanisms underlying host resistance/susceptibility to GAS infection in these 2 mouse strains. Resolution of GAS infection in BALB/c mice correlated with effective control of bacterial proliferation and moderate inflammatory response. In contrast, C3H/HeN mice failed to control bacterial growth and, in response to infection, produced a vigorous inflammatory reaction that resulted in extensive tissue destruction, organ failure, and death. In addition, in response to in vitro stimulation with GAS products, spleen cells from C3H/HeN mice had stronger proliferative activity and greater IFN-gamma production than did those from BALB/c mice. Therefore, the failure to restrict bacterial growth, the concomitant high levels of bacterial products, and the genetic predisposition to produce high levels of inflammatory mediators seem to be responsible for the susceptibility of C3H/HeN mice to GAS infection.