Peroxisome Morphology in Pathologies

Peroxisome Morphology in Pathologies
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病理学中的过氧化物酶体形态

DOI:
10.1007/978-3-7091-1788-0_7
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发表时间:
2014
影响因子:
2
通讯作者:
M. Islinger
M. Islinger
中科院分区:
生物学4区
文献类型:
--
作者:
M. Schrader;I. Castro;H. Fahimi;M. Islinger

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Peroxisomes are ubiquitous and heterogeneous multi-purpose organelles, which are indispensable for human health and development. The invention of specific cytochemical staining methods for peroxisomes revealed their high plasticity and ability to alter their morphology in response to environmental cues. Peroxisome dynamics depend on peroxisomal morphology proteins such as Pex11p, DLP1/Drp1, Fis1, Mff, and GDAP1 which are partially shared with mitochondria. Here, we address variations of peroxisome morphology in the healthy organism and summarize findings on altered organelle morphology in peroxisomal disorders. We highlight recent insights in novel disorders with defects in peroxisome morphology proteins and alterations of peroxisomes during stress and signaling, as well as secondary alterations in liver disease and cancer.
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