Best strategies for global HCV eradication.

Best strategies for global HCV eradication.
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DOI:
10.1111/liv.12063
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发表时间:
2013-02
期刊:
Liver international : official journal of the International Association for the Study of the Liver
影响因子:
--
通讯作者:
Schinazi RF
Schinazi RF
中科院分区:
其他
文献类型:
--
作者:
Hagan LM;Schinazi RF

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通过结合预防教育、普遍的临床和有针对性的社区筛查、与护理的有效联系以及采用有希望的新型直接作用抗病毒药物疗法的治疗,全世界范围内消灭丙型肝炎病毒(HCV)是可能的。应在所有医疗保健就诊中提供普遍筛查,并行社区筛查工作应优先考虑高患病率、高传播人群,包括注射吸毒者、监狱囚犯和 HIV/HCV 双重感染者。通过筛查提高对丙型肝炎病毒感染的认识,通过提供护理和更有效的治疗联系来提高治疗接受率和治愈率,并最终将教育工作与疫苗接种运动结合起来以防止传播和再感染,可以减缓并最终阻止“无声的流行病”。
Worldwide eradication of hepatitis C virus (HCV) is possible through a combination of prevention education, universal clinical and targeted community screening, effective linkage to care, and treatment with promising new direct-acting antiviral drug regimens. Universal screening should be offered in all healthcare visits, and parallel community screening efforts should prioritize high-prevalence, high-transmission populations including injection drug users, prison inmates, and those with HIV/HCV co-infection. Increasing awareness of HCV infection through screening, improving treatment uptake and cure rates by providing linkage to care and more effective treatment, and ultimately combining education efforts with vaccination campaigns to prevent transmission and reinfection can slow and eventually stop the “silent epidemic.”
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