Rivaroxaban in Recurrent Ischemic Stroke Due to Protein S Deficiency: A Case Report.

Rivaroxaban in Recurrent Ischemic Stroke Due to Protein S Deficiency: A Case Report.
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利伐沙班治疗蛋白S缺乏导致的复发性缺血性卒中:病例报告。

DOI:
10.1007/s40120-021-00232-9
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发表时间:
2021-06
影响因子:
3.7
通讯作者:
Adibi I
Adibi I
中科院分区:
医学3区
文献类型:
--
作者:
Naghavi S;Pourmohammadi A;Adibi I

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蛋白S缺乏是一种血栓形成倾向,与血栓栓塞风险增加相关。以往的研究表明其作为静脉血栓栓塞的诱发因素,但其在复发性动脉缺血性卒中中的作用仍不确定。在这里,我们报告一个病人反复缺血性中风由于蛋白S缺乏症。维生素K拮抗剂(VKA)药物口服抗凝治疗用于治疗和预防血栓形成倾向引起的血栓栓塞事件,但有很多局限性,特别是在复发性血栓栓塞事件的情况下。与VKA相比,直接口服抗凝剂(DOAC)具有许多优势。以前的研究表明,它们在血栓形成倾向的情况下是安全的,但它们在由于蛋白S缺乏引起的复发性缺血性卒中中没有得到很好的研究。在本研究中,我们的患者接受利伐沙班治疗。蛋白S缺乏可能是复发性缺血性卒中的诱发因素,利伐沙班可能是一种安全有效的治疗选择。需要进一步的研究来证实我们的发现。
Protein S deficiency is a thrombophilia associated with an increased risk of thromboembolism. Previous studies have shown its role as a predisposing factor for venous thromboembolism, but its role in recurrent arterial ischemic stroke remains uncertain. Here we report a patient with recurrent ischemic stroke due to protein S deficiency. Oral anticoagulant treatment with vitamin K antagonist (VKA) drugs is used to treat and prevent thromboembolic events caused by thrombophilia, but it has many limitations, especially in the case of recurrent thromboembolic events. Direct oral anticoagulants (DOACs) have many advantages over VKA. Previous studies have shown that they are safe in cases of thrombophilia, but they are not well studied in recurrent ischemic stroke due to protein S deficiency. In this study our patient was treated with rivaroxaban. Protein S deficiency may be a predisposing factor in recurrent ischemic stroke, and rivaroxaban can be a safe and effective treatment option. Further studies are needed to confirm our findings.
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