Epigenetics in cancer stem cells.
Epigenetics in cancer stem cells.
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DOI：
10.1186/s12943-017-0596-9
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发表时间：
2017-02-01
期刊：
影响因子：
37.3
通讯作者：
Chow EK
中科院分区：
文献类型：
--
作者：
Toh TB;Lim JJ;Chow EK
令人信服的证据表明，大块肿瘤可以产生于通常被称为“癌症干细胞”的独特细胞亚群，这被认为是肿瘤发生的强大驱动力和治疗耐药性的关键机制。表观基因组学的最新进展揭示了表观遗传调控促进癌症进展的关键机制。在这篇综述中，我们讨论了各种表观遗传途径的放松是如何促进癌症的发生和肿瘤发生的，特别是在癌症干细胞的维持和存活方面。这一信息，加上几项有前景的表观遗传调节药物的临床和临床前试验，为靶向癌症干细胞以及整体改善癌症治疗提供了新的可能性。
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recent advances in epigenomics have illuminated key mechanisms by which epigenetic regulation contribute to cancer progression. In this review, we present a discussion of how deregulation of various epigenetic pathways can contribute to cancer initiation and tumorigenesis, particularly with respect to maintenance and survival of cancer stem cells. This information, together with several promising clinical and preclinical trials of epigenetic modulating drugs, offer new possibilities for targeting cancer stem cells as well as improving cancer therapy overall.