THE RECEPTOR FOR CILIARY NEUROTROPHIC FACTOR
THE RECEPTOR FOR CILIARY NEUROTROPHIC FACTOR
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DOI：
10.1126/science.1648265
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发表时间：
1991-07-05
期刊：
影响因子：
56.9
通讯作者：
YANCOPOULOS, GD
中科院分区：
文献类型：
--
作者：
DAVIS, S;ALDRICH, TH;YANCOPOULOS, GD
虽然神经营养因子最初是基于其支持神经元存活的能力而分离的，但这些分子现在被认为影响神经系统发育和维持的许多方面。识别这些神经营养因子的受体有助于识别这些因子作用的细胞，并有助于理解其确切的作用机制。一个“标记配体淘选”程序被用来克隆睫状神经营养因子（CNTF）的受体。该受体仅在神经系统和骨骼肌内表达。CNTF受体的结构与神经营养分子的神经生长因子家族所利用的受体无关，但与细胞因子白细胞介素-6的受体最同源。这种相似性表明，CNTF受体，像白细胞介素-6受体，需要第二个，信号转导组件。与所有已知的受体相反，CNTF受体通过糖基-磷脂酰肌醇键固定在细胞膜上。
Although neurotrophic factors were originally isolated on the basis of their ability to support the survival of neurons, these molecules are now thought to influence many aspects of the development and maintenance of the nervous system. Identifying the receptors for these neurotrophic factors should aid in identifying the cells on which these factors act and in understanding their precise mechanisms of action. A "tagged-ligand panning" procedure was used to clone a receptor for ciliary neurotrophic factor (CNTF). This receptor is expressed exclusively within the nervous system and skeletal muscle. The CNTF receptor has a structure unrelated to the receptors utilized by the nerve growth factor family of neurotrophic molecules, but instead is most homologous to the receptor for a cytokine, interleukin-6. This similarity suggests that the CNTF receptor, like the interleukin-6 receptor, requires a second, signal-transducing component. In contrast to all known receptors, the CNTF receptor is anchored to cell membranes by a glycosyl-phosphatidylinositol linkage.