Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance
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DOI：
10.1038/s41467-018-07748-z
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发表时间：
2018-12-19
影响因子：
16.6
通讯作者：
Ruiz-Linares, Andres
中科院分区：
文献类型：
--
作者：
Chacon-Duque, Juan-Camilo;Adhikari, Kaustubh;Ruiz-Linares, Andres
历史记录和遗传分析表明，拉丁美洲人的祖先主要是美洲原住民、欧洲人和撒哈拉以南非洲人的混合（混合）。使用基于单倍型的新方法，我们在这里推断6,500多名拉丁美洲人的次大陆血统，并评估区域血统变化对身体外观的影响。我们发现，美洲原住民血统组件在拉丁美洲人在地理上对应于当今的遗传结构的土著群体，和非土著血统的来源，和混合时间，匹配记录的迁移流。我们还发现南/东地中海的祖先在拉丁美洲，可能主要源于秘密的殖民移民的非欧洲血统的基督教皈依者（Conversos）。此外，我们发现，祖先与高地（中安第斯山脉）与低地（马普切人）的土著人与面部特征的变化，特别是鼻子形态，并检测这些群体之间的等位基因频率在本样本中以前与鼻子形态相关的基因座的显着差异。
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of regional ancestry variation on physical appearance. We find that Native American ancestry components in Latin Americans correspond geographically to the present-day genetic structure of Native groups, and that sources of non-Native ancestry, and admixture timings, match documented migratory flows. We also detect South/East Mediterranean ancestry across Latin America, probably stemming mostly from the clandestine colonial migration of Christian converts of non-European origin (Conversos). Furthermore, we find that ancestry related to highland (Central Andean) versus lowland (Mapuche) Natives is associated with variation in facial features, particularly nose morphology, and detect significant differences in allele frequencies between these groups at loci previously associated with nose morphology in this sample.